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2i1a

From Proteopedia

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{{Seed}}
 
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[[Image:2i1a.png|left|200px]]
 
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==A Retroviral Protease-Like Domain in the Eukaryotic Protein Ddi1==
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The line below this paragraph, containing "STRUCTURE_2i1a", creates the "Structure Box" on the page.
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<StructureSection load='2i1a' size='340' side='right'caption='[[2i1a]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2i1a]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I1A FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i1a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1a OCA], [https://pdbe.org/2i1a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i1a RCSB], [https://www.ebi.ac.uk/pdbsum/2i1a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i1a ProSAT]</span></td></tr>
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{{STRUCTURE_2i1a| PDB=2i1a | SCENE= }}
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</table>
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== Function ==
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===A Retroviral Protease-Like Domain in the Eukaryotic Protein Ddi1===
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[https://www.uniprot.org/uniprot/DDI1_YEAST DDI1_YEAST] Acts as a linker between the 19S proteasome and polyubiquitinated proteins like the HO endonuclease and UFO1 via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control. Appears to act as negative regulator of constitutive exocytosis. May act at the level of secretory vesicle docking and fusion as a competitive inhibitor of SNARE assembly.<ref>PMID:10330187</ref> <ref>PMID:11238935</ref> <ref>PMID:12051757</ref> <ref>PMID:12925750</ref> <ref>PMID:15964793</ref> <ref>PMID:17144915</ref> <ref>PMID:16478980</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 17010377 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i1/2i1a_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_17010377}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i1a ConSurf].
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2I1A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1A OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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Ddi1, a eukaryotic protein with the retroviral protease fold., Sirkis R, Gerst JE, Fass D, J Mol Biol. 2006 Dec 1;364(3):376-87. Epub 2006 Sep 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17010377 17010377]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Fass D]]
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[[Category: Fass, D.]]
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[[Category: Sirkis R]]
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[[Category: Sirkis, R.]]
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[[Category: Acid protease fold]]
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[[Category: Dimer]]
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[[Category: Retroviral protease domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:32:51 2008''
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Current revision

A Retroviral Protease-Like Domain in the Eukaryotic Protein Ddi1

PDB ID 2i1a

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