1zoy

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{{Seed}}
 
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[[Image:1zoy.png|left|200px]]
 
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==Crystal Structure of Mitochondrial Respiratory Complex II from porcine heart at 2.4 Angstroms==
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The line below this paragraph, containing "STRUCTURE_1zoy", creates the "Structure Box" on the page.
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<StructureSection load='1zoy' size='340' side='right'caption='[[1zoy]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1zoy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZOY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZOY FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPH:L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE'>EPH</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=UQ1:UBIQUINONE-1'>UQ1</scene></td></tr>
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{{STRUCTURE_1zoy| PDB=1zoy | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zoy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zoy OCA], [https://pdbe.org/1zoy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zoy RCSB], [https://www.ebi.ac.uk/pdbsum/1zoy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zoy ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SDHA_PIG SDHA_PIG] Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zo/1zoy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zoy ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The mitochondrial respiratory Complex II or succinate:ubiquinone oxidoreductase (SQR) is an integral membrane protein complex in both the tricarboxylic acid cycle and aerobic respiration. Here we report the first crystal structure of Complex II from porcine heart at 2.4 A resolution and its complex structure with inhibitors 3-nitropropionate and 2-thenoyltrifluoroacetone (TTFA) at 3.5 A resolution. Complex II is comprised of two hydrophilic proteins, flavoprotein (Fp) and iron-sulfur protein (Ip), and two transmembrane proteins (CybL and CybS), as well as prosthetic groups required for electron transfer from succinate to ubiquinone. The structure correlates the protein environments around prosthetic groups with their unique midpoint redox potentials. Two ubiquinone binding sites are discussed and elucidated by TTFA binding. The Complex II structure provides a bona fide model for study of the mitochondrial respiratory system and human mitochondrial diseases related to mutations in this complex.
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===Crystal Structure of Mitochondrial Respiratory Complex II from porcine heart at 2.4 Angstroms===
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Crystal structure of mitochondrial respiratory membrane protein complex II.,Sun F, Huo X, Zhai Y, Wang A, Xu J, Su D, Bartlam M, Rao Z Cell. 2005 Jul 1;121(7):1043-57. PMID:15989954<ref>PMID:15989954</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1zoy" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_15989954}}, adds the Publication Abstract to the page
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*[[Succinate dehydrogenase 3D structures|Succinate dehydrogenase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15989954 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15989954}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZOY OCA].
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[[Category: Sus scrofa]]
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[[Category: Bartlam M]]
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==Reference==
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[[Category: Huo X]]
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Crystal structure of mitochondrial respiratory membrane protein complex II., Sun F, Huo X, Zhai Y, Wang A, Xu J, Su D, Bartlam M, Rao Z, Cell. 2005 Jul 1;121(7):1043-57. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15989954 15989954]
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[[Category: Rao Z]]
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[[Category: Bartlam, M.]]
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[[Category: Su D]]
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[[Category: Huo, X.]]
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[[Category: Sun F]]
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[[Category: Rao, Z.]]
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[[Category: Wang A]]
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[[Category: Su, D.]]
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[[Category: Xu J]]
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[[Category: Sun, F.]]
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[[Category: Zhai Y]]
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[[Category: Wang, A.]]
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[[Category: Xu, J.]]
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[[Category: Zhai, Y.]]
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[[Category: Membrane protein structure]]
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[[Category: Mitochondrial respiratory complex ii]]
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[[Category: Succinate]]
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[[Category: Ubiquinone oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:34:14 2008''
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Current revision

Crystal Structure of Mitochondrial Respiratory Complex II from porcine heart at 2.4 Angstroms

PDB ID 1zoy

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