1t3a

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:35, 14 February 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1t3a.png|left|200px]]
 
-
<!--
+
==Crystal structure of Clostridium botulinum neurotoxin type E catalytic domain==
-
The line below this paragraph, containing "STRUCTURE_1t3a", creates the "Structure Box" on the page.
+
<StructureSection load='1t3a' size='340' side='right'caption='[[1t3a]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1t3a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T3A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T3A FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.16&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
{{STRUCTURE_1t3a| PDB=1t3a | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t3a OCA], [https://pdbe.org/1t3a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t3a RCSB], [https://www.ebi.ac.uk/pdbsum/1t3a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t3a ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/BXE_CLOBO BXE_CLOBO] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the 180-Arg-|-Ile-181 bond in SNAP-25.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t3/1t3a_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t3a ConSurf].
 +
<div style="clear:both"></div>
-
===Crystal structure of Clostridium botulinum neurotoxin type E catalytic domain===
+
==See Also==
-
 
+
*[[Botulinum neurotoxin 3D structures|Botulinum neurotoxin 3D structures]]
-
 
+
__TOC__
-
<!--
+
</StructureSection>
-
The line below this paragraph, {{ABSTRACT_PUBMED_15157097}}, adds the Publication Abstract to the page
+
-
(as it appears on PubMed at http://www.pubmed.gov), where 15157097 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_15157097}}
+
-
 
+
-
==About this Structure==
+
-
1T3A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T3A OCA].
+
-
 
+
-
==Reference==
+
-
Structural analysis of botulinum neurotoxin type E catalytic domain and its mutant Glu212--&gt;Gln reveals the pivotal role of the Glu212 carboxylate in the catalytic pathway., Agarwal R, Eswaramoorthy S, Kumaran D, Binz T, Swaminathan S, Biochemistry. 2004 Jun 1;43(21):6637-44. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15157097 15157097]
+
-
[[Category: Bontoxilysin]]
+
[[Category: Clostridium botulinum]]
[[Category: Clostridium botulinum]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Agarwal, R.]]
+
[[Category: Agarwal R]]
-
[[Category: Binz, T.]]
+
[[Category: Binz T]]
-
[[Category: Eswaramoorthy, S.]]
+
[[Category: Eswaramoorthy S]]
-
[[Category: Kumaran, D.]]
+
[[Category: Kumaran D]]
-
[[Category: Swaminathan, S.]]
+
[[Category: Swaminathan S]]
-
[[Category: Catalytic domain]]
+
-
[[Category: Clostridium botulinum]]
+
-
[[Category: Light chain]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:40:04 2008''
+

Current revision

Crystal structure of Clostridium botulinum neurotoxin type E catalytic domain

PDB ID 1t3a

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1t3a"
Personal tools