3d0b

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{{Seed}}
 
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[[Image:3d0b.png|left|200px]]
 
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==Crystal Structure of Benzamide Tetrahydro-4H-carbazol-4-one bound to Hsp90==
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The line below this paragraph, containing "STRUCTURE_3d0b", creates the "Structure Box" on the page.
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<StructureSection load='3d0b' size='340' side='right'caption='[[3d0b]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3d0b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D0B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D0B FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SNX:2-[(2-METHOXYETHYL)AMINO]-4-(4-OXO-1,2,3,4-TETRAHYDRO-9H-CARBAZOL-9-YL)BENZAMIDE'>SNX</scene></td></tr>
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{{STRUCTURE_3d0b| PDB=3d0b | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d0b OCA], [https://pdbe.org/3d0b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d0b RCSB], [https://www.ebi.ac.uk/pdbsum/3d0b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d0b ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d0/3d0b_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3d0b ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of Benzamide Tetrahydro-4H-carbazol-4-one bound to Hsp90===
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==See Also==
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
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== References ==
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 18511277 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_18511277}}
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==About this Structure==
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3D0B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D0B OCA].
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==Reference==
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Discovery of benzamide tetrahydro-4H-carbazol-4-ones as novel small molecule inhibitors of Hsp90., Barta TE, Veal JM, Rice JW, Partridge JM, Fadden RP, Ma W, Jenks M, Geng L, Hanson GJ, Huang KH, Barabasz AF, Foley BE, Otto J, Hall SE, Bioorg Med Chem Lett. 2008 Jun 15;18(12):3517-21. Epub 2008 May 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18511277 18511277]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Barta, T E.]]
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[[Category: Barta TE]]
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[[Category: Hall, S H.]]
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[[Category: Hall SH]]
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[[Category: Huang, K H.]]
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[[Category: Huang KH]]
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[[Category: Veal, J M.]]
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[[Category: Veal JM]]
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[[Category: Alternative splicing]]
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[[Category: Atp-binding]]
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[[Category: Chaperone]]
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[[Category: Cytoplasm]]
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[[Category: Heat shock protein 90]]
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[[Category: Hsp90]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphoprotein]]
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[[Category: Stress response]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:47:40 2008''
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Current revision

Crystal Structure of Benzamide Tetrahydro-4H-carbazol-4-one bound to Hsp90

PDB ID 3d0b

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