1q6b

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{{Seed}}
 
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[[Image:1q6b.png|left|200px]]
 
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==Solution Structure of the C-terminal Domain of Thermosynechococcus elongatus KaiA (ThKaiA180C); Ensemble of 25 Structures==
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The line below this paragraph, containing "STRUCTURE_1q6b", creates the "Structure Box" on the page.
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<StructureSection load='1q6b' size='340' side='right'caption='[[1q6b]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1q6b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermosynechococcus_vestitus_BP-1 Thermosynechococcus vestitus BP-1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q6B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q6B FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 25 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q6b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q6b OCA], [https://pdbe.org/1q6b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q6b RCSB], [https://www.ebi.ac.uk/pdbsum/1q6b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q6b ProSAT]</span></td></tr>
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{{STRUCTURE_1q6b| PDB=1q6b | SCENE= }}
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q6/1q6b_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q6b ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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KaiA is a two-domain circadian clock protein in cyanobacteria, acting as the positive element in a feedback loop that sustains the oscillation. The structure of the N-terminal domain of KaiA is that of a pseudo-receiver, similar to those of bacterial response regulators, which likely interacts with components of the clock-resetting pathway. The C-terminal domain of KaiA is highly conserved among cyanobacteria and enhances the autokinase activity of KaiC. Here we present the NMR structure of the C-terminal domain of KaiA from the thermophilic cyanobacterium Thermosynechococcus elongatus BP-1. This domain adopts a novel all alpha-helical homodimeric structure. Several mutations known to affect the period of the circadian oscillator are shown to be located at an exposed groove near the dimer interface. This NMR structure and a 21-A-resolution electron microscopy structure of the hexameric KaiC particle allow us to postulate a mode of KaiA-KaiC interaction, in which KaiA binds a linker region connecting two globular KaiC domains.
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===Solution Structure of the C-terminal Domain of Thermosynechococcus elongatus KaiA (ThKaiA180C); Ensemble of 25 Structures===
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NMR structure of the KaiC-interacting C-terminal domain of KaiA, a circadian clock protein: implications for KaiA-KaiC interaction.,Vakonakis I, Sun J, Wu T, Holzenburg A, Golden SS, LiWang AC Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1479-84. Epub 2004 Jan 28. PMID:14749515<ref>PMID:14749515</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1q6b" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Circadian clock protein 3D structures|Circadian clock protein 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 14749515 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_14749515}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1Q6B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacteria Bacteria]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q6B OCA].
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[[Category: Thermosynechococcus vestitus BP-1]]
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[[Category: Golden SS]]
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==Reference==
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[[Category: Holzenburg A]]
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NMR structure of the KaiC-interacting C-terminal domain of KaiA, a circadian clock protein: implications for KaiA-KaiC interaction., Vakonakis I, Sun J, Wu T, Holzenburg A, Golden SS, LiWang AC, Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1479-84. Epub 2004 Jan 28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14749515 14749515]
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[[Category: LiWang AC]]
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[[Category: Bacteria]]
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[[Category: Sun J]]
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[[Category: Single protein]]
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[[Category: Vakonakis I]]
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[[Category: Golden, S S.]]
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[[Category: Holzenburg, A.]]
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[[Category: LiWang, A C.]]
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[[Category: Sun, J.]]
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[[Category: Vakonakis, I.]]
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[[Category: All alpha-helix protein]]
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[[Category: Homodimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:50:11 2008''
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Current revision

Solution Structure of the C-terminal Domain of Thermosynechococcus elongatus KaiA (ThKaiA180C); Ensemble of 25 Structures

PDB ID 1q6b

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