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1urz

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{{Seed}}
 
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[[Image:1urz.png|left|200px]]
 
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==Low pH induced, membrane fusion conformation of the envelope protein of tick-borne encephalitis virus==
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The line below this paragraph, containing "STRUCTURE_1urz", creates the "Structure Box" on the page.
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<StructureSection load='1urz' size='340' side='right'caption='[[1urz]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1urz]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Tick-borne_encephalitis_virus_(WESTERN_SUBTYPE) Tick-borne encephalitis virus (WESTERN SUBTYPE)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1URZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1URZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1urz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1urz OCA], [https://pdbe.org/1urz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1urz RCSB], [https://www.ebi.ac.uk/pdbsum/1urz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1urz ProSAT]</span></td></tr>
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{{STRUCTURE_1urz| PDB=1urz | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q80E47_9FLAV Q80E47_9FLAV]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ur/1urz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1urz ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Enveloped viruses enter cells via a membrane fusion reaction driven by conformational changes of specific viral envelope proteins. We report here the structure of the ectodomain of the tick-borne encephalitis virus envelope glycoprotein, E, a prototypical class II fusion protein, in its trimeric low-pH-induced conformation. We show that, in the conformational transition, the three domains of the neutral-pH form are maintained but their relative orientation is altered. Similar to the postfusion class I proteins, the subunits rearrange such that the fusion peptide loops cluster at one end of an elongated molecule and the C-terminal segments, connecting to the viral transmembrane region, run along the sides of the trimer pointing toward the fusion peptide loops. Comparison with the low-pH-induced form of the alphavirus class II fusion protein reveals striking differences at the end of the molecule bearing the fusion peptides, suggesting an important conformational effect of the missing membrane connecting segment.
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===LOW PH INDUCED, MEMBRANE FUSION CONFORMATION OF THE ENVELOPE PROTEIN OF TICK-BORNE ENCEPHALITIS VIRUS===
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Structure of a flavivirus envelope glycoprotein in its low-pH-induced membrane fusion conformation.,Bressanelli S, Stiasny K, Allison SL, Stura EA, Duquerroy S, Lescar J, Heinz FX, Rey FA EMBO J. 2004 Feb 25;23(4):728-38. Epub 2004 Feb 12. PMID:14963486<ref>PMID:14963486</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_14963486}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1urz" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 14963486 is the PubMed ID number.
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== References ==
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-->
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<references/>
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{{ABSTRACT_PUBMED_14963486}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1URZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Tick-borne_encephalitis_virus Tick-borne encephalitis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1URZ OCA].
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[[Category: Bressanelli S]]
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[[Category: Rey FA]]
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==Reference==
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Structure of a flavivirus envelope glycoprotein in its low-pH-induced membrane fusion conformation., Bressanelli S, Stiasny K, Allison SL, Stura EA, Duquerroy S, Lescar J, Heinz FX, Rey FA, EMBO J. 2004 Feb 25;23(4):728-38. Epub 2004 Feb 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14963486 14963486]
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[[Category: Single protein]]
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[[Category: Tick-borne encephalitis virus]]
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[[Category: Bressanelli, S.]]
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[[Category: Rey, F A.]]
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[[Category: Envelope protein]]
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[[Category: Membrane fusion]]
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[[Category: Virus/viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:14:55 2008''
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Current revision

Low pH induced, membrane fusion conformation of the envelope protein of tick-borne encephalitis virus

PDB ID 1urz

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