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1zle

From Proteopedia

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{{Seed}}
 
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[[Image:1zle.png|left|200px]]
 
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==Crystal structure of a RGD-containing host-selective toxin: Pyrenophora tritici-repentis Ptr ToxA==
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The line below this paragraph, containing "STRUCTURE_1zle", creates the "Structure Box" on the page.
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<StructureSection load='1zle' size='340' side='right'caption='[[1zle]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1zle]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrenophora_tritici-repentis Pyrenophora tritici-repentis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZLE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZLE FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
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{{STRUCTURE_1zle| PDB=1zle | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zle OCA], [https://pdbe.org/1zle PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zle RCSB], [https://www.ebi.ac.uk/pdbsum/1zle PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zle ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/P78737_9PLEO P78737_9PLEO]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Tan spot of wheat (Triticum aestivum), caused by the fungus Pyrenophora tritici-repentis, has significant agricultural and economic impact. Ptr ToxA (ToxA), the first discovered proteinaceous host-selective toxin, is produced by certain P. tritici-repentis races and is necessary and sufficient to cause cell death in sensitive wheat cultivars. We present here the high-resolution crystal structure of ToxA in two different crystal forms, providing four independent views of the protein. ToxA adopts a single-domain, beta-sandwich fold of novel topology. Mapping of the existing mutation data onto the structure supports the hypothesized importance of an Arg-Gly-Asp (RGD) and surrounding sequence. Its occurrence in a single, solvent-exposed loop in the protein suggests that it is directly involved in recognition events required for ToxA action. Furthermore, the ToxA structure reveals a surprising similarity with the classic mammalian RGD-containing domain, the fibronectin type III (FnIII) domain: the two topologies are related by circular permutation. The similar topologies and the positional conservation of the RGD-containing loop raises the possibility that ToxA is distantly related to mammalian FnIII proteins and that to gain entry it binds to an integrin-like receptor in the plant host.
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===Crystal structure of a RGD-containing host-selective toxin: Pyrenophora tritici-repentis Ptr ToxA===
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Structure of Ptr ToxA: an RGD-containing host-selective toxin from Pyrenophora tritici-repentis.,Sarma GN, Manning VA, Ciuffetti LM, Karplus PA Plant Cell. 2005 Nov;17(11):3190-202. Epub 2005 Oct 7. PMID:16214901<ref>PMID:16214901</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_16214901}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1zle" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16214901 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16214901}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1ZLE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrenophora_tritici-repentis Pyrenophora tritici-repentis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZLE OCA].
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==Reference==
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Structure of Ptr ToxA: an RGD-containing host-selective toxin from Pyrenophora tritici-repentis., Sarma GN, Manning VA, Ciuffetti LM, Karplus PA, Plant Cell. 2005 Nov;17(11):3190-202. Epub 2005 Oct 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16214901 16214901]
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[[Category: Pyrenophora tritici-repentis]]
[[Category: Pyrenophora tritici-repentis]]
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[[Category: Single protein]]
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[[Category: Ciuffetti LM]]
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[[Category: Ciuffetti, L M.]]
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[[Category: Karplus PA]]
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[[Category: Karplus, P A.]]
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[[Category: Manning VA]]
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[[Category: Manning, V A.]]
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[[Category: Sarma GN]]
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[[Category: Sarma, G N.]]
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[[Category: Beta-sandwich]]
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[[Category: Rgd-motif]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:15:33 2008''
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Current revision

Crystal structure of a RGD-containing host-selective toxin: Pyrenophora tritici-repentis Ptr ToxA

PDB ID 1zle

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