3bqo

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:12, 30 August 2023) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3bqo.png|left|200px]]
 
-
<!--
+
==Crystal Structure of TRF1 TRFH domain and TIN2 peptide complex==
-
The line below this paragraph, containing "STRUCTURE_3bqo", creates the "Structure Box" on the page.
+
<StructureSection load='3bqo' size='340' side='right'caption='[[3bqo]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3bqo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BQO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BQO FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bqo OCA], [https://pdbe.org/3bqo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bqo RCSB], [https://www.ebi.ac.uk/pdbsum/3bqo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bqo ProSAT]</span></td></tr>
-
{{STRUCTURE_3bqo| PDB=3bqo | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/TERF1_HUMAN TERF1_HUMAN] Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.<ref>PMID:16166375</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bq/3bqo_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bqo ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Mammalian telomeres are protected by a six-protein complex, shelterin. Shelterin contains two closely related proteins, TRF1 and TRF2, which recruit various proteins to telomeres. Here we dissect the interactions of TRF1 and TRF2 with their shared binding partner, TIN2, and other shelterin accessory factors. TRF1 recognizes TIN2 using a conserved molecular surface in its TRF homology (TRFH) domain. However, this same surface does not act as a TIN2 binding site in TRF2, and TIN2 binding to TRF2 is mediated by a region outside the TRFH domain. Instead, the TRFH docking site of TRF2 binds a shelterin accessory factor Apollo, which does not interact with the TRFH domain of TRF1. Conversely, the TRFH domain of TRF1, but not of TRF2, interacts with another shelterin associated factor PinX1.
-
===Crystal Structure of TRF1 TRFH domain and TIN2 peptide complex===
+
A Shared Docking Motif in TRF1 and TRF2 Used for Differential Recruitment of Telomeric Proteins.,Chen Y, Yang Y, van Overbeek M, Donigian JR, Baciu P, de Lange T, Lei M Science. 2008 Jan 17;. PMID:18202258<ref>PMID:18202258</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_18202258}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 3bqo" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 18202258 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_18202258}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
3BQO is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BQO OCA].
+
-
 
+
-
==Reference==
+
-
A Shared Docking Motif in TRF1 and TRF2 Used for Differential Recruitment of Telomeric Proteins., Chen Y, Yang Y, van Overbeek M, Donigian JR, Baciu P, de Lange T, Lei M, Science. 2008 Jan 17;. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18202258 18202258]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Protein complex]]
+
[[Category: Large Structures]]
-
[[Category: Baciu, P.]]
+
[[Category: Baciu P]]
-
[[Category: Chen, Y.]]
+
[[Category: Chen Y]]
-
[[Category: Donigian, J R.]]
+
[[Category: Donigian JR]]
-
[[Category: Lange, T de.]]
+
[[Category: Lei M]]
-
[[Category: Lei, M.]]
+
[[Category: Yang Y]]
-
[[Category: Overbeek, M van.]]
+
[[Category: De Lange T]]
-
[[Category: Yang, Y.]]
+
[[Category: Van Overbeek M]]
-
[[Category: Adp-ribosylation]]
+
-
[[Category: Alternative splicing]]
+
-
[[Category: Cell cycle]]
+
-
[[Category: Cell division]]
+
-
[[Category: Chromosomal protein]]
+
-
[[Category: Dna binding protein]]
+
-
[[Category: Dna-binding]]
+
-
[[Category: Mitosis]]
+
-
[[Category: Nucleus]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Telomere]]
+
-
[[Category: Trf1 trfh domain dimerization domain tin2]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:16:12 2008''
+

Current revision

Crystal Structure of TRF1 TRFH domain and TIN2 peptide complex

PDB ID 3bqo

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3bqo"
Personal tools