1wzz

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{{Seed}}
 
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[[Image:1wzz.png|left|200px]]
 
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==Structure of endo-beta-1,4-glucanase CMCax from Acetobacter xylinum==
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The line below this paragraph, containing "STRUCTURE_1wzz", creates the "Structure Box" on the page.
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<StructureSection load='1wzz' size='340' side='right'caption='[[1wzz]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1wzz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Komagataeibacter_xylinus Komagataeibacter xylinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WZZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1wzz| PDB=1wzz | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wzz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wzz OCA], [https://pdbe.org/1wzz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wzz RCSB], [https://www.ebi.ac.uk/pdbsum/1wzz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wzz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GUNA_NOVHA GUNA_NOVHA]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wz/1wzz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wzz ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Previous studies have demonstrated that endoglucanase is required for cellulose biosynthesis both in bacteria and plants. However, it has yet to be elucidated how the endoglucanases function in the mechanism of cellulose biosynthesis. Here we describe the crystal structure of the cellulose biosynthesis-related endo-beta-1,47-glucanase (CMCax; EC 3.2.1.4) from the cellulose-producing Gramnegative bacterium, Acetobacter xylinum (= Gluconacetobacter xylinus), determined at 1.65-A resolution. CMCax falls into the glycoside hydrolase family 8 (GH-8), and the structure showed that the overall fold of the CMCax is similar to those of other glycoside hydrolases belonging to GH-8. Structure comparison with Clostridium thermocellum CelA, the best characterized GH-8 endoglucanase, revealed that sugar recognition subsite +3 is completely missing in CMCax. The absence of the subsite +3 leads to significant broadness of the cleft at the cellooligosaccharide reducing-end side. CMCax is known to be a secreted enzyme and is present in the culture medium. However, electron microscopic analysis using immunostaining clearly demonstrated that a portion of CMCax is localized to the cell surface, suggesting a link with other known membrane-anchored endoglucanases that are required for cellulose biosynthesis.
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===Structure of endo-beta-1,4-glucanase CMCax from Acetobacter xylinum===
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Structural characterization of the Acetobacter xylinum endo-beta-1,4-glucanase CMCax required for cellulose biosynthesis.,Yasutake Y, Kawano S, Tajima K, Yao M, Satoh Y, Munekata M, Tanaka I Proteins. 2006 Sep 1;64(4):1069-77. PMID:16804941<ref>PMID:16804941</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1wzz" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_16804941}}, adds the Publication Abstract to the page
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*[[Glucanase 3D structures|Glucanase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 16804941 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16804941}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Komagataeibacter xylinus]]
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1WZZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gluconacetobacter_xylinus Gluconacetobacter xylinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZZ OCA].
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[[Category: Large Structures]]
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[[Category: Kawano S]]
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==Reference==
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[[Category: Munekata M]]
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Structural characterization of the Acetobacter xylinum endo-beta-1,4-glucanase CMCax required for cellulose biosynthesis., Yasutake Y, Kawano S, Tajima K, Yao M, Satoh Y, Munekata M, Tanaka I, Proteins. 2006 Sep 1;64(4):1069-77. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16804941 16804941]
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[[Category: Satoh Y]]
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[[Category: Cellulase]]
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[[Category: Tajima K]]
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[[Category: Gluconacetobacter xylinus]]
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[[Category: Tanaka I]]
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[[Category: Single protein]]
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[[Category: Yao M]]
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[[Category: Kawano, S.]]
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[[Category: Yasutake Y]]
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[[Category: Munekata, M.]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Satoh, Y.]]
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[[Category: Tajima, K.]]
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[[Category: Tanaka, I.]]
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[[Category: Yao, M.]]
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[[Category: Yasutake, Y.]]
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[[Category: Sgcge]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium for research on gene expression system]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:18:50 2008''
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Current revision

Structure of endo-beta-1,4-glucanase CMCax from Acetobacter xylinum

PDB ID 1wzz

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