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2h14

From Proteopedia

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{{Seed}}
 
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[[Image:2h14.png|left|200px]]
 
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==Crystal of WDR5 (apo-form)==
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The line below this paragraph, containing "STRUCTURE_2h14", creates the "Structure Box" on the page.
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<StructureSection load='2h14' size='340' side='right'caption='[[2h14]], [[Resolution|resolution]] 1.48&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2h14]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H14 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.48&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h14 OCA], [https://pdbe.org/2h14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h14 RCSB], [https://www.ebi.ac.uk/pdbsum/2h14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h14 ProSAT]</span></td></tr>
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{{STRUCTURE_2h14| PDB=2h14 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h1/2h14_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2h14 ConSurf].
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<div style="clear:both"></div>
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===Crystal of WDR5 (apo-form)===
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==See Also==
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*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_16829960}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 16829960 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_16829960}}
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==About this Structure==
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2H14 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H14 OCA].
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==Reference==
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Molecular recognition of histone H3 by the WD40 protein WDR5., Couture JF, Collazo E, Trievel RC, Nat Struct Mol Biol. 2006 Aug;13(8):698-703. Epub 2006 Jul 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16829960 16829960]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Collazo, E.]]
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[[Category: Collazo E]]
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[[Category: Couture, J F.]]
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[[Category: Couture JF]]
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[[Category: Trievel, R C.]]
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[[Category: Trievel RC]]
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[[Category: Beta-propeller]]
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[[Category: Histone]]
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[[Category: Mll]]
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[[Category: Wd-40 repeat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:21:40 2008''
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Current revision

Crystal of WDR5 (apo-form)

PDB ID 2h14

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