2hx6

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{{Seed}}
 
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[[Image:2hx6.png|left|200px]]
 
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==Solution structure analysis of the phage T4 endoribonuclease RegB==
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The line below this paragraph, containing "STRUCTURE_2hx6", creates the "Structure Box" on the page.
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<StructureSection load='2hx6' size='340' side='right'caption='[[2hx6]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2hx6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HX6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HX6 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hx6 OCA], [https://pdbe.org/2hx6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hx6 RCSB], [https://www.ebi.ac.uk/pdbsum/2hx6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hx6 ProSAT]</span></td></tr>
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{{STRUCTURE_2hx6| PDB=2hx6 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/REGB_BPT4 REGB_BPT4] Essential to the early nucleolytic processing of a number of T4 messenger RNAs. Specifically cleaves GGAG sequences found in intergenic regions, mainly in translation initiation sites.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The RegB endoribonuclease participates in the bacteriophage T4 life cycle by favoring early messenger RNA breakdown. RegB specifically cleaves GGAG sequences found in intergenic regions, mainly in translation initiation sites. Its activity is very low but can be enhanced up to 100-fold by the ribosomal 30 S subunit or by ribosomal protein S1. RegB has no significant sequence homology to any known protein. Here we used NMR to solve the structure of RegB and map its interactions with two RNA substrates. We also generated a collection of mutants affected in RegB function. Our results show that, despite the absence of any sequence homology, RegB has structural similarities with two Escherichia coli ribonucleases involved in mRNA inactivation on translating ribosomes: YoeB and RelE. Although these ribonucleases have different catalytic sites, we propose that RegB is a new member of the RelE/YoeB structural and functional family of ribonucleases specialized in mRNA inactivation within the ribosome.
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===Solution structure analysis of the phage T4 endoribonuclease RegB===
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Structural and functional studies of RegB, a new member of a family of sequence-specific ribonucleases involved in mRNA inactivation on the ribosome.,Odaert B, Saida F, Aliprandi P, Durand S, Crechet JB, Guerois R, Laalami S, Uzan M, Bontems F J Biol Chem. 2007 Jan 19;282(3):2019-28. Epub 2006 Oct 17. PMID:17046813<ref>PMID:17046813</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_17046813}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2hx6" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17046813 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17046813}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Escherichia virus T4]]
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2HX6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HX6 OCA].
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[[Category: Large Structures]]
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[[Category: Bontems F]]
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==Reference==
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[[Category: Odaert B]]
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Structural and functional studies of RegB, a new member of a family of sequence-specific ribonucleases involved in mRNA inactivation on the ribosome., Odaert B, Saida F, Aliprandi P, Durand S, Crechet JB, Guerois R, Laalami S, Uzan M, Bontems F, J Biol Chem. 2007 Jan 19;282(3):2019-28. Epub 2006 Oct 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17046813 17046813]
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[[Category: Saida F]]
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[[Category: Enterobacteria phage t4]]
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[[Category: Uzan M]]
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[[Category: Single protein]]
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[[Category: Bontems, F.]]
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[[Category: Odaert, B.]]
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[[Category: Saida, F.]]
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[[Category: Uzan, M.]]
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[[Category: Alpha/beta fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:37:55 2008''
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Current revision

Solution structure analysis of the phage T4 endoribonuclease RegB

PDB ID 2hx6

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