This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1m30
From Proteopedia
(Difference between revisions)
(New page: 200px<br /><applet load="1m30" size="450" color="white" frame="true" align="right" spinBox="true" caption="1m30" /> '''Solution structure of N-terminal SH3 domain ...) |
|||
| (15 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:1m30.gif|left|200px]]<br /><applet load="1m30" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1m30" /> | ||
| - | '''Solution structure of N-terminal SH3 domain from oncogene protein c-Crk'''<br /> | ||
| - | == | + | ==Solution structure of N-terminal SH3 domain from oncogene protein c-Crk== |
| - | + | <StructureSection load='1m30' size='340' side='right'caption='[[1m30]]' scene=''> | |
| - | [ | + | == Structural highlights == |
| - | [[ | + | <table><tr><td colspan='2'>[[1m30]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M30 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M30 FirstGlance]. <br> |
| - | [ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m30 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m30 OCA], [https://pdbe.org/1m30 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m30 RCSB], [https://www.ebi.ac.uk/pdbsum/1m30 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m30 ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | [ | + | == Function == |
| - | [ | + | [https://www.uniprot.org/uniprot/CRK_MOUSE CRK_MOUSE] The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. |
| - | [[ | + | == Evolutionary Conservation == |
| - | [ | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | [[ | + | Check<jmol> |
| - | + | <jmolCheckbox> | |
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m3/1m30_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m30 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| + | *[[Adapter molecule crk 3D structures|Adapter molecule crk 3D structures]] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Camarero JA]] | ||
| + | [[Category: Fushman D]] | ||
| + | [[Category: Hall JB]] | ||
| + | [[Category: Schumann FH]] | ||
| + | [[Category: Tayakuniyil PP]] | ||
| + | [[Category: Varadan R]] | ||
Current revision
Solution structure of N-terminal SH3 domain from oncogene protein c-Crk
| |||||||||||
