2juo

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:42, 9 May 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2juo.png|left|200px]]
 
-
<!--
+
==GABPa OST domain==
-
The line below this paragraph, containing "STRUCTURE_2juo", creates the "Structure Box" on the page.
+
<StructureSection load='2juo' size='340' side='right'caption='[[2juo]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2juo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JUO FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2juo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2juo OCA], [https://pdbe.org/2juo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2juo RCSB], [https://www.ebi.ac.uk/pdbsum/2juo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2juo ProSAT]</span></td></tr>
-
{{STRUCTURE_2juo| PDB=2juo | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/GABPA_MOUSE GABPA_MOUSE] Transcription factor capable of interacting with purine rich repeats (GA repeats).
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/2juo_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2juo ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Using NMR spectroscopy, we identified and characterized a previously unrecognized structured domain near the N-terminus (residues 35-121) of the ETS family transcription factor GABP alpha. The monomeric domain folds as a five-stranded beta-sheet crossed by a distorted helix. Although globally resembling ubiquitin, the GABP alpha fragment differs in its secondary structure topology and thus appears to represent a new protein fold that we term the OST (On-SighT) domain. The surface of the GABP alpha OST domain contains two predominant clusters of negatively-charged residues suggestive of electrostatically driven interactions with positively-charged partner proteins. Following a best-candidate approach to identify such a partner, we demonstrated through NMR-monitored titrations and glutathione S-transferase pulldown assays that the OST domain binds to the CH1 and CH3 domains of the co-activator histone acetyltransferase CBP/p300. This provides a direct structural link between GABP and a central component of the transcriptional machinery.
-
===GABPa OST domain===
+
Identification and structural characterization of a CBP/p300-binding domain from the ETS family transcription factor GABP alpha.,Kang HS, Nelson ML, Mackereth CD, Scharpf M, Graves BJ, McIntosh LP J Mol Biol. 2008 Mar 28;377(3):636-46. Epub 2008 Jan 30. PMID:18295234<ref>PMID:18295234</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_18295234}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 2juo" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 18295234 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_18295234}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
2JUO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUO OCA].
+
-
 
+
-
==Reference==
+
-
Identification and structural characterization of a CBP/p300-binding domain from the ETS family transcription factor GABP alpha., Kang HS, Nelson ML, Mackereth CD, Scharpf M, Graves BJ, McIntosh LP, J Mol Biol. 2008 Mar 28;377(3):636-46. Epub 2008 Jan 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18295234 18295234]
+
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Single protein]]
+
[[Category: Graves BJ]]
-
[[Category: Graves, B J.]]
+
[[Category: Kang H]]
-
[[Category: Kang, H.]]
+
[[Category: Mackereth CD]]
-
[[Category: Mackereth, C D.]]
+
[[Category: McIntosh LP]]
-
[[Category: McIntosh, L P.]]
+
[[Category: Nelson ML]]
-
[[Category: Nelson, M L.]]
+
[[Category: Schaerpf M]]
-
[[Category: Schaerpf, M.]]
+
-
[[Category: Dna-binding]]
+
-
[[Category: Ga-binding protein]]
+
-
[[Category: Nmr ensemble]]
+
-
[[Category: Nucleus]]
+
-
[[Category: Ost]]
+
-
[[Category: Transcription factor]]
+
-
[[Category: Transcription regulation]]
+
-
[[Category: Ubiquitin]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:14:10 2008''
+

Current revision

GABPa OST domain

PDB ID 2juo

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2juo"
Personal tools