2e3m

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{{Seed}}
 
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[[Image:2e3m.png|left|200px]]
 
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==Crystal structure of CERT START domain==
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The line below this paragraph, containing "STRUCTURE_2e3m", creates the "Structure Box" on the page.
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<StructureSection load='2e3m' size='340' side='right'caption='[[2e3m]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2e3m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E3M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E3M FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e3m OCA], [https://pdbe.org/2e3m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e3m RCSB], [https://www.ebi.ac.uk/pdbsum/2e3m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e3m ProSAT]</span></td></tr>
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{{STRUCTURE_2e3m| PDB=2e3m | SCENE= }}
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</table>
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== Disease ==
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===Crystal structure of CERT START domain===
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[https://www.uniprot.org/uniprot/CERT_HUMAN CERT_HUMAN] The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/CERT_HUMAN CERT_HUMAN] Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner.<ref>PMID:14685229</ref> <ref>PMID:17591919</ref> <ref>PMID:18184806</ref> <ref>PMID:20036255</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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(as it appears on PubMed at http://www.pubmed.gov), where 18184806 is the PubMed ID number.
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Check<jmol>
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{{ABSTRACT_PUBMED_18184806}}
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e3/2e3m_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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==About this Structure==
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<text>to colour the structure by Evolutionary Conservation</text>
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2E3M is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E3M OCA].
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e3m ConSurf].
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==Reference==
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<div style="clear:both"></div>
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Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide., Kudo N, Kumagai K, Tomishige N, Yamaji T, Wakatsuki S, Nishijima M, Hanada K, Kato R, Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):488-93. Epub 2008 Jan 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18184806 18184806]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Hanada, K.]]
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[[Category: Hanada K]]
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[[Category: Kato, R.]]
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[[Category: Kato R]]
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[[Category: Kudo, N.]]
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[[Category: Kudo N]]
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[[Category: Kumagai, K.]]
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[[Category: Kumagai K]]
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[[Category: Nishijima, M.]]
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[[Category: Nishijima M]]
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[[Category: Wakatsuki, S.]]
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[[Category: Wakatsuki S]]
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[[Category: Ceramide transfer]]
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[[Category: Cert]]
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[[Category: Lipid transfer protein]]
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[[Category: Lipid transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:30:16 2008''
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Current revision

Crystal structure of CERT START domain

PDB ID 2e3m

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