2b1o

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{{Seed}}
 
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[[Image:2b1o.png|left|200px]]
 
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==Solution Structure of Ca2+-bound DdCAD-1==
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The line below this paragraph, containing "STRUCTURE_2b1o", creates the "Structure Box" on the page.
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<StructureSection load='2b1o' size='340' side='right'caption='[[2b1o]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2b1o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B1O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B1O FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_2b1o| PDB=2b1o | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b1o OCA], [https://pdbe.org/2b1o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b1o RCSB], [https://www.ebi.ac.uk/pdbsum/2b1o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b1o ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CAD1_DICDI CAD1_DICDI] Mediates calcium-dependent cell-cell adhesion during the early stage of development.<ref>PMID:8663243</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b1/2b1o_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b1o ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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DdCAD-1 is a novel Ca(2+)-dependent cell adhesion molecule that lacks a hydrophobic signal peptide and a transmembrane domain. DdCAD-1 is expressed by the social amoeba Dictyostelium discoideum at the onset of development. It is synthesized as a soluble protein and then transported to the plasma membrane by contractile vacuoles. Here we describe the novel features of the solution structures of Ca(2+)-free and Ca(2+)-bound monomeric DdCAD-1. DdCAD-1 contains two beta-sandwich domains, belonging to the betagamma-crystallin and immunoglobulin fold classes, respectively. Whereas the N-terminal domain has a major role in homophilic binding, the C-terminal domain tethers the protein to the cell membrane. From structural and mutational analyses, we propose a model for the Ca(2+)-bound DdCAD-1 dimer as a basis for understanding DdCAD-1-mediated cell-cell adhesion at the molecular level. Our results provide new insights into Ca(2+)-dependent mechanisms for cell-cell adhesion.
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===Solution Structure of Ca2+-bound DdCAD-1===
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Solution structures of the adhesion molecule DdCAD-1 reveal new insights into Ca(2+)-dependent cell-cell adhesion.,Lin Z, Sriskanthadevan S, Huang H, Siu CH, Yang D Nat Struct Mol Biol. 2006 Nov;13(11):1016-22. Epub 2006 Oct 22. PMID:17057715<ref>PMID:17057715</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17057715}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2b1o" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17057715 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17057715}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2B1O is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B1O OCA].
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==Reference==
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Solution structures of the adhesion molecule DdCAD-1 reveal new insights into Ca(2+)-dependent cell-cell adhesion., Lin Z, Sriskanthadevan S, Huang H, Siu CH, Yang D, Nat Struct Mol Biol. 2006 Nov;13(11):1016-22. Epub 2006 Oct 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17057715 17057715]
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(1)H, (13)C and (15)N resonance assignments of Ca(2+)-free DdCAD-1: a Ca(2+)-dependent cell-cell adhesion molecule., Lin Z, Huang H, Siu CH, Yang D, J Biomol NMR. 2004 Nov;30(3):375-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15756470 15756470]
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[[Category: Dictyostelium discoideum]]
[[Category: Dictyostelium discoideum]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Huang, H B.]]
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[[Category: Huang HB]]
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[[Category: Lin, Z.]]
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[[Category: Lin Z]]
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[[Category: Siu, C H.]]
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[[Category: Siu CH]]
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[[Category: Sriskanthadevan, S.]]
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[[Category: Sriskanthadevan S]]
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[[Category: Yang, D W.]]
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[[Category: Yang DW]]
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[[Category: Calcium]]
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[[Category: Cell adherison]]
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[[Category: Cell adhesion]]
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[[Category: Ddcad-1]]
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[[Category: Nmr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:34:17 2008''
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Current revision

Solution Structure of Ca2+-bound DdCAD-1

PDB ID 2b1o

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OCA

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