2d3j

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (05:09, 17 October 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2d3j.png|left|200px]]
 
-
<!--
+
==NMR structure of the WIF domain from human WIF-1==
-
The line below this paragraph, containing "STRUCTURE_2d3j", creates the "Structure Box" on the page.
+
<StructureSection load='2d3j' size='340' side='right'caption='[[2d3j]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2d3j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D3J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D3J FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d3j OCA], [https://pdbe.org/2d3j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d3j RCSB], [https://www.ebi.ac.uk/pdbsum/2d3j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d3j ProSAT]</span></td></tr>
-
{{STRUCTURE_2d3j| PDB=2d3j | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/WIF1_HUMAN WIF1_HUMAN] Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d3/2d3j_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d3j ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The human Wnt-binding protein Wnt-inhibitory factor-1 (WIF-1) comprises an N-terminal WIF module followed by five EGF-like repeats. Here we report the three-dimensional structure of the WIF domain of WIF-1 determined by NMR spectroscopy. The fold consists of an eight-stranded beta-sandwich reminiscent of the immunoglobulin fold. Residual detergent (Brij-35) used in the refolding protocol was found to bind tightly to the WIF domain. The binding site was identified by intermolecular nuclear Overhauser effects observed between the WIF domain and the alkyl chain of the detergent. The results point to a possible role of WIF domains as a recognition motif of Wnt and Drosophila Hedgehog proteins that are activated by palmitoylation.
-
===NMR structure of the WIF domain from human WIF-1===
+
NMR structure of the WIF domain of the human Wnt-inhibitory factor-1.,Liepinsh E, Banyai L, Patthy L, Otting G J Mol Biol. 2006 Mar 31;357(3):942-50. Epub 2006 Jan 31. PMID:16476441<ref>PMID:16476441</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_16476441}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 2d3j" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 16476441 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_16476441}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
2D3J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D3J OCA].
+
-
 
+
-
==Reference==
+
-
NMR structure of the WIF domain of the human Wnt-inhibitory factor-1., Liepinsh E, Banyai L, Patthy L, Otting G, J Mol Biol. 2006 Mar 31;357(3):942-50. Epub 2006 Jan 31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16476441 16476441]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Banyai, L.]]
+
[[Category: Banyai L]]
-
[[Category: Liepinsh, E.]]
+
[[Category: Liepinsh E]]
-
[[Category: Otting, G.]]
+
[[Category: Otting G]]
-
[[Category: Patthy, L.]]
+
[[Category: Patthy L]]
-
[[Category: Palmitoyl group]]
+
-
[[Category: Recognition domain]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:37:45 2008''
+

Current revision

NMR structure of the WIF domain from human WIF-1

PDB ID 2d3j

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2d3j"
Personal tools