2ic6

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[[Image:2ic6.png|left|200px]]
 
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==The Coiled-coil Domain (residues 1-75) Structure of the Sin Nombre Virus Nucleocapsid Protein==
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The line below this paragraph, containing "STRUCTURE_2ic6", creates the "Structure Box" on the page.
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<StructureSection load='2ic6' size='340' side='right'caption='[[2ic6]], [[Resolution|resolution]] 1.15&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ic6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sin_Nombre_orthohantavirus Sin Nombre orthohantavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IC6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IC6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.15&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ic6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ic6 OCA], [https://pdbe.org/2ic6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ic6 RCSB], [https://www.ebi.ac.uk/pdbsum/2ic6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ic6 ProSAT]</span></td></tr>
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{{STRUCTURE_2ic6| PDB=2ic6 | SCENE= }}
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</table>
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== Function ==
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===The Coiled-coil Domain (residues 1-75) Structure of the Sin Nombre Virus Nucleocapsid Protein===
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[https://www.uniprot.org/uniprot/NCAP_SINV NCAP_SINV] Encapsidates the genome protecting it from nucleases (Probable). The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for transcription and replication (Probable). The nucleocapsid has a left-handed helical structure (By similarity). As a trimer, specifically binds and acts as a chaperone to unwind the panhandle structure formed by the viral RNA (vRNA) termini (PubMed:15650206, PubMed:15254200, PubMed:21378500, PubMed:16971445, PubMed:25062117, PubMed:16775315). Involved in the transcription and replication initiation of vRNA by mediating primer annealing (PubMed:20164193). Plays a role in cap snatching by sequestering capped RNAs in P bodies for use by the viral RdRp during transcription initiation (PubMed:19047634). Substitutes for the cellular cap-binding complex (eIF4F) to preferentially facilitate the translation of capped mRNAs (PubMed:18971945, PubMed:25062117). Initiates the translation by specifically binding to the cap and 40S ribosomal subunit (PubMed:20844026, PubMed:20164193, PubMed:25062117). Prevents the viral glycoprotein N (Gn) from autophagy-dependent breakdown maybe by blocking autophagosome formation (By similarity). Inhibits host EIF2AK2/PKR dimerization to prevent PKR-induced translational shutdown in cells and thus the activation of the antiviral state (By similarity). Also displays sequence-unspecific DNA endonuclease activity (PubMed:27261891).[UniProtKB:O36307][UniProtKB:P05133]<ref>PMID:15254200</ref> <ref>PMID:15650206</ref> <ref>PMID:16775315</ref> <ref>PMID:16971445</ref> <ref>PMID:18971945</ref> <ref>PMID:19047634</ref> <ref>PMID:20164193</ref> <ref>PMID:20844026</ref> <ref>PMID:21378500</ref> <ref>PMID:25062117</ref> <ref>PMID:27261891</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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(as it appears on PubMed at http://www.pubmed.gov), where 17222867 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ic/2ic6_consurf.spt"</scriptWhenChecked>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ic6 ConSurf].
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2IC6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sin_nombre_virus Sin nombre virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IC6 OCA].
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== References ==
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==Reference==
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<references/>
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The coiled-coil domain structure of the Sin Nombre virus nucleocapsid protein., Boudko SP, Kuhn RJ, Rossmann MG, J Mol Biol. 2007 Mar 9;366(5):1538-44. Epub 2006 Dec 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17222867 17222867]
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__TOC__
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[[Category: Sin nombre virus]]
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</StructureSection>
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Boudko, S P.]]
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[[Category: Sin Nombre orthohantavirus]]
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[[Category: Rossmann, M G.]]
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[[Category: Boudko SP]]
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[[Category: Antiparallel coiled coil]]
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[[Category: Rossmann MG]]
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[[Category: Bunyaviridae]]
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[[Category: Hantavirus]]
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[[Category: Nucleocapsid protein]]
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[[Category: Sin nombre virus]]
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[[Category: Ssrna negative-strand viruse]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:47:05 2008''
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Current revision

The Coiled-coil Domain (residues 1-75) Structure of the Sin Nombre Virus Nucleocapsid Protein

PDB ID 2ic6

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