2g9l

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{{Seed}}
 
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[[Image:2g9l.png|left|200px]]
 
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==The High-resolution Solution Conformation of an Antimicrobial Peptide Gaegurin 4 and Its Mode of Membrane Interaction==
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The line below this paragraph, containing "STRUCTURE_2g9l", creates the "Structure Box" on the page.
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<StructureSection load='2g9l' size='340' side='right'caption='[[2g9l]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2g9l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Glandirana_rugosa Glandirana rugosa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G9L FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 15 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g9l OCA], [https://pdbe.org/2g9l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g9l RCSB], [https://www.ebi.ac.uk/pdbsum/2g9l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g9l ProSAT]</span></td></tr>
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{{STRUCTURE_2g9l| PDB=2g9l | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GGN4_GLARU GGN4_GLARU] Has a non-hemolytic activity. Has a broad spectrum of activity against both Gram-positive and Gram-negative bacteria, fungi and protozoa.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We have applied NMR spectroscopy to determine the high-resolution structure of gaegurin 4, a 37-residue antimicrobial peptide from Rana rugosa, under varying hydrophobic conditions. Even in 100% H2O, gaegurin 4 contains a nascent turn near its C-terminal Rana box. Under a more hydrophobic condition it forms two amphipathic helices, one long encompassing residues 2-23 and the other consisting of residues 25-34, similar to what has been observed in cecropin A. Functional implication of the helix-breaking kink at Gly24 in gaegurin 4 was investigated by preparing several analogs. Based upon the current and previous results, we propose a novel seaanemone-like ion pore-forming model for gaegurin 4.
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===The High-resolution Solution Conformation of an Antimicrobial Peptide Gaegurin 4 and Its Mode of Membrane Interaction===
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Solution structure and membrane interaction mode of an antimicrobial peptide gaegurin 4.,Chi SW, Kim JS, Kim DH, Lee SH, Park YH, Han KH Biochem Biophys Res Commun. 2007 Jan 19;352(3):592-7. Epub 2006 Nov 27. PMID:17141187<ref>PMID:17141187</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_17141187}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2g9l" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17141187 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17141187}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Glandirana rugosa]]
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2G9L is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9L OCA].
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[[Category: Large Structures]]
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[[Category: Chi S-W]]
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==Reference==
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[[Category: Han K-H]]
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Solution structure and membrane interaction mode of an antimicrobial peptide gaegurin 4., Chi SW, Kim JS, Kim DH, Lee SH, Park YH, Han KH, Biochem Biophys Res Commun. 2007 Jan 19;352(3):592-7. Epub 2006 Nov 27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17141187 17141187]
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[[Category: Single protein]]
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[[Category: Chi, S W.]]
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[[Category: Han, K H.]]
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[[Category: Amphipathic helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:52:08 2008''
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Current revision

The High-resolution Solution Conformation of an Antimicrobial Peptide Gaegurin 4 and Its Mode of Membrane Interaction

PDB ID 2g9l

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