2gkn

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{{Seed}}
 
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[[Image:2gkn.png|left|200px]]
 
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==Crystal structure of Mycobacterium tuberculosis trHbN, GlnE11Val mutant==
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The line below this paragraph, containing "STRUCTURE_2gkn", creates the "Structure Box" on the page.
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<StructureSection load='2gkn' size='340' side='right'caption='[[2gkn]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2gkn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GKN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GKN FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CYN:CYANIDE+ION'>CYN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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{{STRUCTURE_2gkn| PDB=2gkn | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gkn OCA], [https://pdbe.org/2gkn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gkn RCSB], [https://www.ebi.ac.uk/pdbsum/2gkn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gkn ProSAT]</span></td></tr>
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</table>
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===Crystal structure of Mycobacterium tuberculosis trHbN, GlnE11Val mutant===
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== Function ==
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[https://www.uniprot.org/uniprot/TRHBN_MYCTU TRHBN_MYCTU] Binds oxygen cooperatively with very high affinity (P(50) = 0.013 mmHg at 20 degrees Celsius) because of a fast combination (25 microM(-1).s(-1)) and a slow dissociation (0.2 s(-1)) rate.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 16846220 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gk/2gkn_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_16846220}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2GKN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GKN OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gkn ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Ligand interactions in the distal heme pocket of Mycobacterium tuberculosis truncated hemoglobin N: roles of TyrB10 and GlnE11 residues., Ouellet Y, Milani M, Couture M, Bolognesi M, Guertin M, Biochemistry. 2006 Jul 25;45(29):8770-81. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16846220 16846220]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Single protein]]
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[[Category: Bolognesi M]]
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[[Category: Bolognesi, M.]]
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[[Category: Milani M]]
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[[Category: Milani, M.]]
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[[Category: Mutant]]
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[[Category: Truncated hemoglobin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:02:22 2008''
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Current revision

Crystal structure of Mycobacterium tuberculosis trHbN, GlnE11Val mutant

PDB ID 2gkn

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