1xaw

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{{Seed}}
 
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[[Image:1xaw.png|left|200px]]
 
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==crystal structure of the cytoplasmic distal C-terminal domain of occludin==
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The line below this paragraph, containing "STRUCTURE_1xaw", creates the "Structure Box" on the page.
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<StructureSection load='1xaw' size='340' side='right'caption='[[1xaw]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1xaw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XAW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XAW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xaw OCA], [https://pdbe.org/1xaw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xaw RCSB], [https://www.ebi.ac.uk/pdbsum/1xaw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xaw ProSAT]</span></td></tr>
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{{STRUCTURE_1xaw| PDB=1xaw | SCENE= }}
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</table>
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== Disease ==
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===crystal structure of the cytoplasmic distal C-terminal domain of occludin===
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[https://www.uniprot.org/uniprot/OCLN_HUMAN OCLN_HUMAN] Defects in OCLN are the cause of band-like calcification with simplified gyration and polymicrogyria (BLCPMG) [MIM:[https://omim.org/entry/251290 251290]; also known as pseudo-TORCH syndrome. BLCPMG is a neurologic disorder with characteristic clinical and neuroradiologic features that mimic intrauterine TORCH infection in the absence of evidence of infection. Affected individuals have congenital microcephaly, intracranial calcifications, and severe developmental delay.<ref>PMID:20727516</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/OCLN_HUMAN OCLN_HUMAN] May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions.<ref>PMID:19114660</ref>
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== Evolutionary Conservation ==
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The line below this paragraph, {{ABSTRACT_PUBMED_16081103}}, adds the Publication Abstract to the page
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[[Image:Consurf_key_small.gif|200px|right]]
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(as it appears on PubMed at http://www.pubmed.gov), where 16081103 is the PubMed ID number.
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Check<jmol>
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<jmolCheckbox>
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{{ABSTRACT_PUBMED_16081103}}
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xa/1xaw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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==About this Structure==
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<text>to colour the structure by Evolutionary Conservation</text>
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1XAW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XAW OCA].
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xaw ConSurf].
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==Reference==
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<div style="clear:both"></div>
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Structure of the conserved cytoplasmic C-terminal domain of occludin: identification of the ZO-1 binding surface., Li Y, Fanning AS, Anderson JM, Lavie A, J Mol Biol. 2005 Sep 9;352(1):151-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16081103 16081103]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Anderson, J M.]]
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[[Category: Anderson JM]]
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[[Category: Fanning, A S.]]
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[[Category: Fanning AS]]
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[[Category: Lavie, A.]]
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[[Category: Lavie A]]
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[[Category: Li, Y.]]
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[[Category: Li Y]]
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[[Category: Coiled-coil]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:03:23 2008''
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Current revision

crystal structure of the cytoplasmic distal C-terminal domain of occludin

PDB ID 1xaw

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