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2b18

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{{Seed}}
 
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[[Image:2b18.png|left|200px]]
 
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==N-terminal GAF domain of transcriptional pleiotropic repressor CodY.==
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The line below this paragraph, containing "STRUCTURE_2b18", creates the "Structure Box" on the page.
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<StructureSection load='2b18' size='340' side='right'caption='[[2b18]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2b18]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B18 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B18 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ILE:ISOLEUCINE'>ILE</scene></td></tr>
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{{STRUCTURE_2b18| PDB=2b18 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b18 OCA], [https://pdbe.org/2b18 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b18 RCSB], [https://www.ebi.ac.uk/pdbsum/2b18 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b18 ProSAT]</span></td></tr>
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</table>
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===N-terminal GAF domain of transcriptional pleiotropic repressor CodY.===
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== Function ==
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[https://www.uniprot.org/uniprot/CODY_BACSU CODY_BACSU] DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase and sporulation. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor.<ref>PMID:8830686</ref> <ref>PMID:11331605</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 16488888 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b1/2b18_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_16488888}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2B18 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B18 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b18 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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The structure of CodY, a GTP- and isoleucine-responsive regulator of stationary phase and virulence in gram-positive bacteria., Levdikov VM, Blagova E, Joseph P, Sonenshein AL, Wilkinson AJ, J Biol Chem. 2006 Apr 21;281(16):11366-73. Epub 2006 Feb 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16488888 16488888]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Blagova, E.]]
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[[Category: Blagova E]]
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[[Category: Joseph, P.]]
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[[Category: Joseph P]]
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[[Category: Levdikov, V M.]]
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[[Category: Levdikov VM]]
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[[Category: Sonenshein, A L.]]
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[[Category: Sonenshein AL]]
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[[Category: Wilkinson, A J.]]
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[[Category: Wilkinson AJ]]
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[[Category: Branched chain amino acid binding.]]
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[[Category: Cody]]
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[[Category: Dna-binding]]
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[[Category: Gaf domain]]
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[[Category: Nucleotide-binding]]
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[[Category: Repressor]]
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[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:10:16 2008''
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Current revision

N-terminal GAF domain of transcriptional pleiotropic repressor CodY.

PDB ID 2b18

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