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1qtu

From Proteopedia

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{{Seed}}
 
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[[Image:1qtu.png|left|200px]]
 
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<!--
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==SOLUTION STRUCTURE OF THE ONCOPROTEIN P13MTCP1==
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The line below this paragraph, containing "STRUCTURE_1qtu", creates the "Structure Box" on the page.
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<StructureSection load='1qtu' size='340' side='right'caption='[[1qtu]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1qtu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QTU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QTU FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qtu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qtu OCA], [https://pdbe.org/1qtu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qtu RCSB], [https://www.ebi.ac.uk/pdbsum/1qtu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qtu ProSAT]</span></td></tr>
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{{STRUCTURE_1qtu| PDB=1qtu | SCENE= }}
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</table>
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== Disease ==
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===SOLUTION STRUCTURE OF THE ONCOPROTEIN P13MTCP1===
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[https://www.uniprot.org/uniprot/MTCP1_HUMAN MTCP1_HUMAN] Note=Detected in T-cell leukemia bearing a t(X;14) translocation. Plays a key role in T-cell prolymphocytic leukemia.
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== Function ==
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[https://www.uniprot.org/uniprot/MTCP1_HUMAN MTCP1_HUMAN] Enhances the phosphorylation and activation of AKT1 and AKT2.<ref>PMID:10983986</ref>
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<!--
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== Evolutionary Conservation ==
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The line below this paragraph, {{ABSTRACT_PUBMED_10959629}}, adds the Publication Abstract to the page
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[[Image:Consurf_key_small.gif|200px|right]]
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(as it appears on PubMed at http://www.pubmed.gov), where 10959629 is the PubMed ID number.
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Check<jmol>
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<jmolCheckbox>
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{{ABSTRACT_PUBMED_10959629}}
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qt/1qtu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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==About this Structure==
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<text>to colour the structure by Evolutionary Conservation</text>
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1QTU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QTU OCA].
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qtu ConSurf].
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==Reference==
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<div style="clear:both"></div>
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Backbone dynamics and solution structure refinement of the 15N-labeled human oncogenic protein p13MTCP1: comparison with X-ray data., Guignard L, Padilla A, Mispelter J, Yang YS, Stern MH, Lhoste JM, Roumestand C, J Biomol NMR. 2000 Jul;17(3):215-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10959629 10959629]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Guignard, L.]]
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[[Category: Guignard L]]
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[[Category: Lhoste, J-M.]]
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[[Category: Lhoste J-M]]
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[[Category: Mispelter, J.]]
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[[Category: Mispelter J]]
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[[Category: Padilla, A.]]
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[[Category: Padilla A]]
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[[Category: Roumestand, C.]]
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[[Category: Roumestand C]]
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[[Category: Stern, M-H.]]
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[[Category: Stern M-H]]
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[[Category: Yang, Y-S.]]
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[[Category: Yang Y-S]]
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[[Category: Beta barrel]]
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[[Category: Gene regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:12:26 2008''
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Current revision

SOLUTION STRUCTURE OF THE ONCOPROTEIN P13MTCP1

PDB ID 1qtu

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