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1mfp
From Proteopedia
(Difference between revisions)
(New page: 200px<br /><applet load="1mfp" size="450" color="white" frame="true" align="right" spinBox="true" caption="1mfp, resolution 2.33Å" /> '''E. coli Enoyl Reduct...) |
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| - | [[Image:1mfp.gif|left|200px]]<br /><applet load="1mfp" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1mfp, resolution 2.33Å" /> | ||
| - | '''E. coli Enoyl Reductase in complex with NAD and SB611113'''<br /> | ||
| - | == | + | ==E. coli Enoyl Reductase in complex with NAD and SB611113== |
| - | + | <StructureSection load='1mfp' size='340' side='right'caption='[[1mfp]], [[Resolution|resolution]] 2.33Å' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1mfp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MFP FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.33Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IDN:(E)-N-METHYL-N-(1-METHYL-1H-INDOL-3-YLMETHYL)-3-(7-OXO-5,6,7,8-TETRAHYDRO-[1,8]NAPHTHYRIDIN-3-YL)-ACRYLAMIDE'>IDN</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mfp OCA], [https://pdbe.org/1mfp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mfp RCSB], [https://www.ebi.ac.uk/pdbsum/1mfp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mfp ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/FABI_ECOLI FABI_ECOLI] Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism and in the biotin biosynthesis.<ref>PMID:8119879</ref> <ref>PMID:7592873</ref> <ref>PMID:20693992</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mf/1mfp_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mfp ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[Enoyl-Acyl-Carrier Protein Reductase 3D structures|Enoyl-Acyl-Carrier Protein Reductase 3D structures]] | |
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Burgess | + | [[Category: Burgess WJ]] |
| - | [[Category: | + | [[Category: DeWolf Jr WE]] |
| - | [[Category: | + | [[Category: Elkins PA]] |
| - | [[Category: | + | [[Category: Head MS]] |
| - | [[Category: | + | [[Category: Huffman WF]] |
| - | [[Category: | + | [[Category: Jakas DR]] |
| - | [[Category: | + | [[Category: Janson CA]] |
| - | [[Category: Keller | + | [[Category: Keller PM]] |
| - | [[Category: Manley | + | [[Category: Manley PJ]] |
| - | [[Category: Miller | + | [[Category: Miller WH]] |
| - | [[Category: Moore | + | [[Category: Moore TD]] |
| - | [[Category: Newlander | + | [[Category: Newlander KA]] |
| - | [[Category: Payne | + | [[Category: Payne DJ]] |
| - | [[Category: Pearson | + | [[Category: Pearson S]] |
| - | [[Category: Polizzi | + | [[Category: Polizzi BJ]] |
| - | [[Category: Qiu | + | [[Category: Qiu X]] |
| - | [[Category: Rittenhouse | + | [[Category: Rittenhouse SF]] |
| - | [[Category: Seefeld | + | [[Category: Seefeld MA]] |
| - | [[Category: Uzinskas | + | [[Category: Uzinskas IN]] |
| - | [[Category: Wallis | + | [[Category: Wallis NG]] |
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Current revision
E. coli Enoyl Reductase in complex with NAD and SB611113
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Categories: Escherichia coli | Large Structures | Burgess WJ | DeWolf Jr WE | Elkins PA | Head MS | Huffman WF | Jakas DR | Janson CA | Keller PM | Manley PJ | Miller WH | Moore TD | Newlander KA | Payne DJ | Pearson S | Polizzi BJ | Qiu X | Rittenhouse SF | Seefeld MA | Uzinskas IN | Wallis NG
