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1mij

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(New page: 200px<br /><applet load="1mij" size="450" color="white" frame="true" align="right" spinBox="true" caption="1mij, resolution 2.05&Aring;" /> '''Crystal Structure of...)
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[[Image:1mij.gif|left|200px]]<br /><applet load="1mij" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1mij, resolution 2.05&Aring;" />
 
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'''Crystal Structure of the Homeo-prospero Domain of D. melanogaster Prospero'''<br />
 
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==Overview==
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==Crystal Structure of the Homeo-prospero Domain of D. melanogaster Prospero==
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The Prospero transcription factor promotes neural differentiation in, Drosophila, and its activity is tightly regulated by modulating its, subcellular localization. Prospero is exported from the nucleus of neural, precursors but imported into the nucleus of daughter cells, which is, necessary for their proper differentiation. Prospero has a highly, divergent putative homeodomain adjacent to a conserved Prospero domain;, both are required for sequence-specific DNA binding. Here we show that the, structure of these two regions consists of a single structural unit (a, homeo-prospero domain), in which the Prospero domain region is in position, to contribute to DNA binding and also to mask a defined nuclear export, signal that is within the putative homeodomain region. We propose that the, homeo-prospero domain coordinately regulates Prospero nuclear localization, and DNA binding specificity.
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<StructureSection load='1mij' size='340' side='right'caption='[[1mij]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1mij]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MIJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MIJ FirstGlance]. <br>
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1MIJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1MIJ OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mij OCA], [https://pdbe.org/1mij PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mij RCSB], [https://www.ebi.ac.uk/pdbsum/1mij PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mij ProSAT]</span></td></tr>
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Structure of the DNA binding region of prospero reveals a novel homeo-prospero domain., Ryter JM, Doe CQ, Matthews BW, Structure. 2002 Nov;10(11):1541-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12429095 12429095]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PROS_DROME PROS_DROME] Required for proper neuronal differentiation of most or all neurons and their precursors in central and peripheral nervous systems, axonal outgrowth and pathfinding. Not required for the specification of neuronal identity. May regulate transcription by binding to DNA.<ref>PMID:1720353</ref> <ref>PMID:1842358</ref> <ref>PMID:1540176</ref> <ref>PMID:11051550</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mi/1mij_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mij ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Doe, C.Q.]]
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[[Category: Doe CQ]]
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[[Category: Matthews, B.W.]]
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[[Category: Matthews BW]]
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[[Category: Ryter, J.M.]]
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[[Category: Ryter JM]]
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[[Category: 4-helix bundle]]
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[[Category: dna-binding domain]]
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[[Category: homeodomain]]
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[[Category: prospero domain]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 21:26:16 2007''
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Current revision

Crystal Structure of the Homeo-prospero Domain of D. melanogaster Prospero

PDB ID 1mij

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