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2r8p

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{{Seed}}
 
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[[Image:2r8p.png|left|200px]]
 
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==Transketolase from E. coli in complex with substrate D-fructose-6-phosphate==
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The line below this paragraph, containing "STRUCTURE_2r8p", creates the "Structure Box" on the page.
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<StructureSection load='2r8p' size='340' side='right'caption='[[2r8p]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2r8p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R8P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R8P FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=T6F:2-C-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-5-(2-{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}ETHYL)-4-METHYL-1,3-THIAZOL-3-IUM-2-YL}-6-O-PHOSPHONO-D-GLUCITOL'>T6F</scene></td></tr>
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{{STRUCTURE_2r8p| PDB=2r8p | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r8p OCA], [https://pdbe.org/2r8p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r8p RCSB], [https://www.ebi.ac.uk/pdbsum/2r8p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r8p ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TKT1_ECOLI TKT1_ECOLI] Catalyzes the reversible transfer of a two-carbon ketol group from sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate, producing xylulose-5-phosphate and ribose-5-phosphate. Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.<ref>PMID:17914867</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r8/2r8p_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r8p ConSurf].
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<div style="clear:both"></div>
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===Transketolase from E. coli in complex with substrate D-fructose-6-phosphate===
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==See Also==
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*[[Transketolase 3D structures|Transketolase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_17914867}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 17914867 is the PubMed ID number.
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</StructureSection>
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[[Category: Escherichia coli K-12]]
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{{ABSTRACT_PUBMED_17914867}}
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[[Category: Large Structures]]
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[[Category: Asztalos P]]
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==About this Structure==
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[[Category: Tittmann K]]
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2R8P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R8P OCA].
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[[Category: Weiss MS]]
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[[Category: Wille G]]
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==Reference==
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Strain and near attack conformers in enzymic thiamin catalysis: X-ray crystallographic snapshots of bacterial transketolase in covalent complex with donor ketoses xylulose 5-phosphate and fructose 6-phosphate, and in noncovalent complex with acceptor aldose ribose 5-phosphate., Asztalos P, Parthier C, Golbik R, Kleinschmidt M, Hubner G, Weiss MS, Friedemann R, Wille G, Tittmann K, Biochemistry. 2007 Oct 30;46(43):12037-52. Epub 2007 Oct 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17914867 17914867]
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[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Transketolase]]
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[[Category: Asztalos, P.]]
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[[Category: Tittmann, K.]]
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[[Category: Weiss, M S.]]
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[[Category: Wille, G.]]
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[[Category: Calcium]]
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[[Category: Metal-binding]]
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[[Category: Reaction intermediate]]
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[[Category: Thiamine pyrophosphate]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:18:45 2008''
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Current revision

Transketolase from E. coli in complex with substrate D-fructose-6-phosphate

PDB ID 2r8p

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