1u09

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{{Seed}}
 
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[[Image:1u09.png|left|200px]]
 
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==Footand Mouth Disease Virus RNA-dependent RNA polymerase==
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The line below this paragraph, containing "STRUCTURE_1u09", creates the "Structure Box" on the page.
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<StructureSection load='1u09' size='340' side='right'caption='[[1u09]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1u09]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Foot-and-mouth_disease_virus_C-S8c1 Foot-and-mouth disease virus C-S8c1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U09 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U09 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.91&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u09 OCA], [https://pdbe.org/1u09 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u09 RCSB], [https://www.ebi.ac.uk/pdbsum/1u09 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u09 ProSAT]</span></td></tr>
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{{STRUCTURE_1u09| PDB=1u09 | SCENE= }}
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</table>
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== Function ==
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===Footand Mouth Disease Virus RNA-dependent RNA polymerase===
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[https://www.uniprot.org/uniprot/Q9QCE4_9PICO Q9QCE4_9PICO] Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266] RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_15294895}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 15294895 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u0/1u09_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_15294895}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u09 ConSurf].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U09 OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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Structure of foot-and-mouth disease virus RNA-dependent RNA polymerase and its complex with a template-primer RNA., Ferrer-Orta C, Arias A, Perez-Luque R, Escarmis C, Domingo E, Verdaguer N, J Biol Chem. 2004 Nov 5;279(45):47212-21. Epub 2004 Aug 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15294895 15294895]
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[[Category: Foot-and-mouth disease virus C-S8c1]]
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[[Category: RNA-directed RNA polymerase]]
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[[Category: Large Structures]]
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[[Category: Arias, A.]]
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[[Category: Arias A]]
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[[Category: Domingo, E.]]
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[[Category: Domingo E]]
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[[Category: Escarmis, C.]]
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[[Category: Escarmis C]]
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[[Category: Ferrer-Orta, C.]]
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[[Category: Ferrer-Orta C]]
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[[Category: Perez-Luque, R.]]
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[[Category: Perez-Luque R]]
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[[Category: Verdaguer, N.]]
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[[Category: Verdaguer N]]
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[[Category: Foot and mouth disease virus]]
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[[Category: Protein-dna complex]]
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[[Category: Rna-dependent rna polymerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:40:48 2008''
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Current revision

Footand Mouth Disease Virus RNA-dependent RNA polymerase

PDB ID 1u09

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