2qh7

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{{Seed}}
 
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[[Image:2qh7.png|left|200px]]
 
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==MitoNEET is a uniquely folded 2Fe-2S outer mitochondrial membrane protein stabilized by pioglitazone==
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The line below this paragraph, containing "STRUCTURE_2qh7", creates the "Structure Box" on the page.
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<StructureSection load='2qh7' size='340' side='right'caption='[[2qh7]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2qh7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QH7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QH7 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene></td></tr>
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{{STRUCTURE_2qh7| PDB=2qh7 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qh7 OCA], [https://pdbe.org/2qh7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qh7 RCSB], [https://www.ebi.ac.uk/pdbsum/2qh7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qh7 ProSAT]</span></td></tr>
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</table>
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===MitoNEET is a uniquely folded 2Fe-2S outer mitochondrial membrane protein stabilized by pioglitazone===
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== Function ==
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[https://www.uniprot.org/uniprot/CISD1_HUMAN CISD1_HUMAN] Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation (By similarity). May be involved in Fe-S cluster shuttling and/or in redox reactions.<ref>PMID:17584744</ref> <ref>PMID:17766440</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 17766440 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qh/2qh7_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_17766440}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2QH7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QH7 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qh7 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane protein stabilized by pioglitazone., Paddock ML, Wiley SE, Axelrod HL, Cohen AE, Roy M, Abresch EC, Capraro D, Murphy AN, Nechushtai R, Dixon JE, Jennings PA, Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14342-7. Epub 2007 Aug 31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17766440 17766440]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Axelrod, H L.]]
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[[Category: Abresch EC]]
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[[Category: Capraro, D.]]
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[[Category: Axelrod HL]]
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[[Category: Cohen, A E.]]
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[[Category: Capraro D]]
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[[Category: Dixon, J E.]]
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[[Category: Cohen AE]]
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[[Category: E C., Abresch..]]
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[[Category: Dixon JE]]
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[[Category: Jennings, P A.]]
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[[Category: Jennings PA]]
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[[Category: Murphy, A N.]]
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[[Category: Murphy AN]]
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[[Category: Nechushtai, R.]]
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[[Category: Nechushtai R]]
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[[Category: Paddock, M L.]]
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[[Category: Paddock ML]]
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[[Category: Roy, M.]]
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[[Category: Roy M]]
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[[Category: Wiley, S E.]]
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[[Category: Wiley SE]]
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[[Category: 2fe-2s protein]]
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[[Category: Metal binding protein]]
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[[Category: Mitoneet]]
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[[Category: Outer mitochrodrial membrane protein]]
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[[Category: Pioglitazone binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:44:20 2008''
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Current revision

MitoNEET is a uniquely folded 2Fe-2S outer mitochondrial membrane protein stabilized by pioglitazone

PDB ID 2qh7

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