2pr2

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{{Seed}}
 
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[[Image:2pr2.png|left|200px]]
 
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==Structure of Mycobacterium tuberculosis enoyl-ACP reductase with bound INH-NADP.==
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The line below this paragraph, containing "STRUCTURE_2pr2", creates the "Structure Box" on the page.
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<StructureSection load='2pr2' size='340' side='right'caption='[[2pr2]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2pr2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PR2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PR2 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DG1:(4S)-ISONICOTINIC-ACETYL-NICOTINAMIDE-ADENINE+DINUCLEOTIDE'>DG1</scene></td></tr>
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{{STRUCTURE_2pr2| PDB=2pr2 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pr2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pr2 OCA], [https://pdbe.org/2pr2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pr2 RCSB], [https://www.ebi.ac.uk/pdbsum/2pr2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pr2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/INHA_MYCTU INHA_MYCTU]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pr/2pr2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pr2 ConSurf].
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<div style="clear:both"></div>
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===Structure of Mycobacterium tuberculosis enoyl-ACP reductase with bound INH-NADP.===
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==See Also==
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*[[Enoyl-Acyl-Carrier Protein Reductase 3D structures|Enoyl-Acyl-Carrier Protein Reductase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2PR2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PR2 OCA].
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[[Category: Large Structures]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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==Reference==
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[[Category: Argyrou A]]
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New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP., Argyrou A, Vetting MW, Blanchard JS, J Am Chem Soc. 2007 Aug 8;129(31):9582-3. Epub 2007 Jul 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17636923 17636923]
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[[Category: Blanchard JS]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Vetting MW]]
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[[Category: Single protein]]
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[[Category: Argyrou, A.]]
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[[Category: Blanchard, J S.]]
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[[Category: Vetting, M W.]]
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[[Category: Drug target of isoniazid]]
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[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:50:56 2008''
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Current revision

Structure of Mycobacterium tuberculosis enoyl-ACP reductase with bound INH-NADP.

PDB ID 2pr2

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