1rr9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:26, 1 May 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1rr9.png|left|200px]]
 
-
<!--
+
==Catalytic domain of E.coli Lon protease==
-
The line below this paragraph, containing "STRUCTURE_1rr9", creates the "Structure Box" on the page.
+
<StructureSection load='1rr9' size='340' side='right'caption='[[1rr9]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1rr9]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RR9 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
{{STRUCTURE_1rr9| PDB=1rr9 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rr9 OCA], [https://pdbe.org/1rr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rr9 RCSB], [https://www.ebi.ac.uk/pdbsum/1rr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rr9 ProSAT]</span></td></tr>
-
 
+
</table>
-
===Catalytic domain of E.coli Lon protease===
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/LON_ECOLI LON_ECOLI] ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins, including some antitoxins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. Endogenous substrates include the regulatory proteins RcsA and SulA, the transcriptional activator SoxS, and UmuD. Its overproduction specifically inhibits translation through at least two different pathways, one of them being the YoeB-YefM toxin-antitoxin system.<ref>PMID:12135363</ref> <ref>PMID:16584195</ref> <ref>PMID:19721064</ref>
-
 
+
== Evolutionary Conservation ==
-
<!--
+
[[Image:Consurf_key_small.gif|200px|right]]
-
The line below this paragraph, {{ABSTRACT_PUBMED_14665623}}, adds the Publication Abstract to the page
+
Check<jmol>
-
(as it appears on PubMed at http://www.pubmed.gov), where 14665623 is the PubMed ID number.
+
<jmolCheckbox>
-
-->
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rr/1rr9_consurf.spt"</scriptWhenChecked>
-
{{ABSTRACT_PUBMED_14665623}}
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
 
+
<text>to colour the structure by Evolutionary Conservation</text>
-
==About this Structure==
+
</jmolCheckbox>
-
1RR9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RR9 OCA].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rr9 ConSurf].
-
 
+
<div style="clear:both"></div>
-
==Reference==
+
== References ==
-
The catalytic domain of Escherichia coli Lon protease has a unique fold and a Ser-Lys dyad in the active site., Botos I, Melnikov EE, Cherry S, Tropea JE, Khalatova AG, Rasulova F, Dauter Z, Maurizi MR, Rotanova TV, Wlodawer A, Gustchina A, J Biol Chem. 2004 Feb 27;279(9):8140-8. Epub 2003 Dec 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14665623 14665623]
+
<references/>
-
[[Category: Endopeptidase La]]
+
__TOC__
 +
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Botos, I.]]
+
[[Category: Botos I]]
-
[[Category: Cherry, S.]]
+
[[Category: Cherry S]]
-
[[Category: Dauter, Z.]]
+
[[Category: Dauter Z]]
-
[[Category: Gustchina, A.]]
+
[[Category: Gustchina A]]
-
[[Category: Khalatova, A G.]]
+
[[Category: Khalatova AG]]
-
[[Category: Maurizi, M R.]]
+
[[Category: Maurizi MR]]
-
[[Category: Melnikov, E E.]]
+
[[Category: Melnikov EE]]
-
[[Category: Rotanova, T V.]]
+
[[Category: Rotanova TV]]
-
[[Category: Tropea, J E.]]
+
[[Category: Tropea JE]]
-
[[Category: Wlodawer, A.]]
+
[[Category: Wlodawer A]]
-
[[Category: Atp-dependent protease]]
+
-
[[Category: Catalytic dyad ser-ly]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:54:03 2008''
+

Current revision

Catalytic domain of E.coli Lon protease

PDB ID 1rr9

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1rr9"
Personal tools