1yny

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{{Seed}}
 
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[[Image:1yny.png|left|200px]]
 
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==Molecular Structure of D-Hydantoinase from a Bacillus sp. AR9: Evidence for mercury inhibition==
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The line below this paragraph, containing "STRUCTURE_1yny", creates the "Structure Box" on the page.
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<StructureSection load='1yny' size='340' side='right'caption='[[1yny]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1yny]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_sp._AR9 Bacillus sp. AR9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YNY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YNY FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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{{STRUCTURE_1yny| PDB=1yny | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yny OCA], [https://pdbe.org/1yny PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yny RCSB], [https://www.ebi.ac.uk/pdbsum/1yny PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yny ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q5DLU2_9BACI Q5DLU2_9BACI]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yn/1yny_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yny ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Stereospecific conversion of hydantoins into their carbamoyl acid derivatives could be achieved by using the enzyme hydantoinase. Specific hydantoinases convert either the D-form or the L-form of the hydantoin and the amino acids responsible for stereospecificity have not been identified. Structural studies on hydantoinases from a few bacterial species were published recently. The structure of a thermostable D-hydantoinase from Bacillus sp. AR9 (bar9HYD) was solved to 2.3 angstroms resolution. The usual modification of carboxylation of the active-site residue Lys150 did not happen in bar9HYD. Two manganese ions were modelled in the active site. Through biochemical studies, it was shown that mercury inhibits the activity of the enzyme. The mercury derivative provided some information about the binding site of the mercuric inhibitors and a possible reason for inhibition is presented.
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===Molecular Structure of D-Hydantoinase from a Bacillus sp. AR9: Evidence for mercury inhibition===
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Molecular structure of D-hydantoinase from Bacillus sp. AR9: evidence for mercury inhibition.,Radha Kishan KV, Vohra RM, Ganesan K, Agrawal V, Sharma VM, Sharma R J Mol Biol. 2005 Mar 18;347(1):95-105. Epub 2005 Jan 27. PMID:15733920<ref>PMID:15733920</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15733920}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1yny" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15733920 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15733920}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Bacillus sp. AR9]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YNY OCA].
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[[Category: Large Structures]]
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[[Category: Agrawal V]]
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==Reference==
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[[Category: Ganeshan K]]
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Molecular structure of D-hydantoinase from Bacillus sp. AR9: evidence for mercury inhibition., Radha Kishan KV, Vohra RM, Ganesan K, Agrawal V, Sharma VM, Sharma R, J Mol Biol. 2005 Mar 18;347(1):95-105. Epub 2005 Jan 27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15733920 15733920]
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[[Category: Radha Kishan KV]]
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[[Category: Dihydropyrimidinase]]
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[[Category: Sharma R]]
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[[Category: Agrawal, V.]]
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[[Category: Sharma VM]]
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[[Category: Ganeshan, K.]]
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[[Category: Vohra RM]]
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[[Category: Kishan, K V.Radha.]]
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[[Category: Sharma, R.]]
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[[Category: Sharma, V M.]]
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[[Category: Vohra, R M.]]
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[[Category: Binuclear metal-binding]]
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[[Category: Hydantoinase]]
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[[Category: Hydrolase]]
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[[Category: Tim-barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:55:53 2008''
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Current revision

Molecular Structure of D-Hydantoinase from a Bacillus sp. AR9: Evidence for mercury inhibition

PDB ID 1yny

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