2tpt

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{{Seed}}
 
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[[Image:2tpt.png|left|200px]]
 
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==STRUCTURAL AND THEORETICAL STUDIES SUGGEST DOMAIN MOVEMENT PRODUCES AN ACTIVE CONFORMATION OF THYMIDINE PHOSPHORYLASE==
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The line below this paragraph, containing "STRUCTURE_2tpt", creates the "Structure Box" on the page.
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<StructureSection load='2tpt' size='340' side='right'caption='[[2tpt]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2tpt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TPT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2TPT FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_2tpt| PDB=2tpt | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2tpt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2tpt OCA], [https://pdbe.org/2tpt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2tpt RCSB], [https://www.ebi.ac.uk/pdbsum/2tpt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2tpt ProSAT]</span></td></tr>
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</table>
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===STRUCTURAL AND THEORETICAL STUDIES SUGGEST DOMAIN MOVEMENT PRODUCES AN ACTIVE CONFORMATION OF THYMIDINE PHOSPHORYLASE===
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== Function ==
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[https://www.uniprot.org/uniprot/TYPH_ECOLI TYPH_ECOLI] The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_9698549}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 9698549 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tp/2tpt_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_9698549}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2TPT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TPT OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2tpt ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Structural and theoretical studies suggest domain movement produces an active conformation of thymidine phosphorylase., Pugmire MJ, Cook WJ, Jasanoff A, Walter MR, Ealick SE, J Mol Biol. 1998 Aug 14;281(2):285-99. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9698549 9698549]
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</StructureSection>
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[[Category: Escherichia coli]]
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[[Category: Escherichia coli K-12]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Thymidine phosphorylase]]
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[[Category: Cook WJ]]
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[[Category: Cook, W J.]]
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[[Category: Ealick SE]]
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[[Category: Ealick, S E.]]
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[[Category: Jasanoff A]]
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[[Category: Jasanoff, A.]]
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[[Category: Pugmire MJ]]
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[[Category: Pugmire, M J.]]
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[[Category: Walter MR]]
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[[Category: Walter, M R.]]
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[[Category: Salvage pathway]]
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[[Category: Thymidine phosphorylase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:59:21 2008''
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Current revision

STRUCTURAL AND THEORETICAL STUDIES SUGGEST DOMAIN MOVEMENT PRODUCES AN ACTIVE CONFORMATION OF THYMIDINE PHOSPHORYLASE

PDB ID 2tpt

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