2csa

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{{Seed}}
 
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[[Image:2csa.png|left|200px]]
 
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==Structure of the M3 Muscarinic Acetylcholine Receptor Basolateral Sorting Signal==
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The line below this paragraph, containing "STRUCTURE_2csa", creates the "Structure Box" on the page.
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<StructureSection load='2csa' size='340' side='right'caption='[[2csa]]' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2csa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CSA FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2csa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2csa OCA], [https://pdbe.org/2csa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2csa RCSB], [https://www.ebi.ac.uk/pdbsum/2csa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2csa ProSAT]</span></td></tr>
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{{STRUCTURE_2csa| PDB=2csa | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/ACM3_HUMAN ACM3_HUMAN] Defects in CHRM3 are the cause of Eagle-Barrett syndrome (EGBRS) [MIM:[https://omim.org/entry/100100 100100]. EGBRS is a syndrome characterized by thin abdominal musculature with overlying lax skin, cryptorchism, megacystis with disorganized detrusor muscle, and urinary tract abnormalities.<ref>PMID:22077972</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/ACM3_HUMAN ACM3_HUMAN] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Muscarinic acetylcholine receptors comprise a family of G-protein-coupled receptors that display differential localization in polarized epithelial cells. We identify a seven-residue sequence, Ala(275)-Val(281), in the third intracellular loop of the M(3) muscarinic receptor that mediates dominant, position-independent basolateral targeting in Madin-Darby canine kidney cells. Mutational analyses identify Glu(276), Phe(280), and Val(281) as critical residues within this sorting motif. Phe(280) and Val(281) comprise a novel dihydrophobic sorting signal as mutations of either residue singly or together with leucine do not disrupt basolateral targeting. Conversely, Glu(276) is required and cannot be substituted with alanine or aspartic acid. A 19-amino acid peptide representing the M(3) sorting signal and surrounding sequence was analyzed via two-dimensional nuclear magnetic resonance spectroscopy. Solution structures show that Glu(276) resides in a type IV beta-turn and the dihydrophobic sequence Phe(280)Val(281) adopts either a type I or IV beta-turn.
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===Structure of the M3 Muscarinic Acetylcholine Receptor Basolateral Sorting Signal===
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Identification and structural determination of the M(3) muscarinic acetylcholine receptor basolateral sorting signal.,Iverson HA, Fox D 3rd, Nadler LS, Klevit RE, Nathanson NM J Biol Chem. 2005 Jul 1;280(26):24568-75. Epub 2005 May 2. PMID:15870063<ref>PMID:15870063</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 2csa" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15870063 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15870063}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Homo sapiens]]
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2CSA is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSA OCA].
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[[Category: Large Structures]]
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[[Category: Fox D]]
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==Reference==
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[[Category: Iverson HA]]
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Identification and structural determination of the M(3) muscarinic acetylcholine receptor basolateral sorting signal., Iverson HA, Fox D 3rd, Nadler LS, Klevit RE, Nathanson NM, J Biol Chem. 2005 Jul 1;280(26):24568-75. Epub 2005 May 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15870063 15870063]
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[[Category: Klevit RE]]
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[[Category: Single protein]]
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[[Category: Nadler LS]]
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[[Category: Fox, D.]]
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[[Category: Nathanson NM]]
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[[Category: Iverson, H A.]]
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[[Category: Klevit, R E.]]
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[[Category: Nadler, L S.]]
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[[Category: Nathanson, N M.]]
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[[Category: Basolateral sorting-signal blss beta-turn]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:00:03 2008''
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Current revision

Structure of the M3 Muscarinic Acetylcholine Receptor Basolateral Sorting Signal

PDB ID 2csa

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