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1q46

From Proteopedia

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{{Seed}}
 
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[[Image:1q46.png|left|200px]]
 
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==crystal structure of the eIF2 alpha subunit from saccharomyces cerevisia==
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The line below this paragraph, containing "STRUCTURE_1q46", creates the "Structure Box" on the page.
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<StructureSection load='1q46' size='340' side='right'caption='[[1q46]], [[Resolution|resolution]] 2.86&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1q46]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q46 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q46 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.86&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q46 OCA], [https://pdbe.org/1q46 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q46 RCSB], [https://www.ebi.ac.uk/pdbsum/1q46 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q46 ProSAT]</span></td></tr>
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{{STRUCTURE_1q46| PDB=1q46 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IF2A_YEAST IF2A_YEAST] eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q4/1q46_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q46 ConSurf].
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<div style="clear:both"></div>
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===crystal structure of the eIF2 alpha subunit from saccharomyces cerevisia===
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==See Also==
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*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_14607111}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 14607111 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14607111}}
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==About this Structure==
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1Q46 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q46 OCA].
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==Reference==
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The crystal structure of the N-terminal region of the alpha subunit of translation initiation factor 2 (eIF2alpha) from Saccharomyces cerevisiae provides a view of the loop containing serine 51, the target of the eIF2alpha-specific kinases., Dhaliwal S, Hoffman DW, J Mol Biol. 2003 Nov 21;334(2):187-95. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14607111 14607111]
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Dhaliwal S]]
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[[Category: Dhaliwal, S.]]
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[[Category: Hoffman DW]]
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[[Category: Hoffman, D W.]]
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[[Category: Eif2]]
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[[Category: Initiation factor]]
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[[Category: Phosphorylation site]]
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[[Category: Translation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:22:28 2008''
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Current revision

crystal structure of the eIF2 alpha subunit from saccharomyces cerevisia

PDB ID 1q46

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