1cx4

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[[Image:1cx4.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF A DELETION MUTANT OF THE TYPE II BETA REGULATORY SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE==
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The line below this paragraph, containing "STRUCTURE_1cx4", creates the "Structure Box" on the page.
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<StructureSection load='1cx4' size='340' side='right'caption='[[1cx4]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1cx4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. The August 2012 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''cAMP-dependent Protein Kinase (PKA)'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2012_8 10.2210/rcsb_pdb/mom_2012_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CX4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CX4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene></td></tr>
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{{STRUCTURE_1cx4| PDB=1cx4 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cx4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cx4 OCA], [https://pdbe.org/1cx4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cx4 RCSB], [https://www.ebi.ac.uk/pdbsum/1cx4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cx4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KAP3_RAT KAP3_RAT] Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cx/1cx4_consurf.spt"</scriptWhenChecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cx4 ConSurf].
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===CRYSTAL STRUCTURE OF A DELETION MUTANT OF THE TYPE II BETA REGULATORY SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE===
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==See Also==
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*[[CAMP-dependent protein kinase 3D structures|CAMP-dependent protein kinase 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 11342137 is the PubMed ID number.
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[[Category: RCSB PDB Molecule of the Month]]
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{{ABSTRACT_PUBMED_11342137}}
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==About this Structure==
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1CX4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CX4 OCA].
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==Reference==
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Molecular basis for regulatory subunit diversity in cAMP-dependent protein kinase: crystal structure of the type II beta regulatory subunit., Diller TC, Madhusudan, Xuong NH, Taylor SS, Structure. 2001 Jan 10;9(1):73-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11342137 11342137]
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Type II beta regulatory subunit of cAMP-dependent protein kinase: purification strategies to optimize crystallization., Diller TC, Xuong NH, Taylor SS, Protein Expr Purif. 2000 Dec;20(3):357-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11087674 11087674]
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Single protein]]
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[[Category: Diller TC]]
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[[Category: Diller, T C.]]
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[[Category: Taylor SS]]
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[[Category: Taylor, S S.]]
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[[Category: Xuong NH]]
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[[Category: Xuong, N H.]]
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[[Category: Beta barrel]]
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[[Category: Camp-binding]]
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[[Category: Camp-dependent protein kinase]]
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[[Category: Regulatory subunit]]
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[[Category: Signaling protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:42:28 2008''
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Current revision

CRYSTAL STRUCTURE OF A DELETION MUTANT OF THE TYPE II BETA REGULATORY SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE

PDB ID 1cx4

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