1mr3

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="1mr3" size="450" color="white" frame="true" align="right" spinBox="true" caption="1mr3, resolution 1.60&Aring;" /> '''Saccharomyces cerevi...)
Current revision (07:47, 14 February 2024) (edit) (undo)
 
(15 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1mr3.gif|left|200px]]<br /><applet load="1mr3" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1mr3, resolution 1.60&Aring;" />
 
-
'''Saccharomyces cerevisiae ADP-ribosylation Factor 2 (ScArf2) complexed with GDP-3'P at 1.6A resolution'''<br />
 
-
==Overview==
+
==Saccharomyces cerevisiae ADP-ribosylation Factor 2 (ScArf2) complexed with GDP-3'P at 1.6A resolution==
-
Structures were determined by x-ray crystallography for two members of the, ADP-ribosylation factor (ARF) family of regulatory GTPases, yeast ARF1 and, ARL1, and were compared with previously determined structures of human, ARF1 and ARF6. These analyses revealed an overall conserved fold but, differences in primary sequence and length, particularly in an N-terminal, loop, lead to differences in nucleotide and divalent metal binding., Packing of hydrophobic residues is central to the interplay between the, N-terminal alpha-helix, switch I, and the interswitch region, which along, with differences in surface electrostatics provide explanations for the, different biophysical and biochemical properties of ARF and ARF-like, proteins.
+
<StructureSection load='1mr3' size='340' side='right'caption='[[1mr3]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==About this Structure==
+
<table><tr><td colspan='2'>[[1mr3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MR3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MR3 FirstGlance]. <br>
-
1MR3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] with MG, G3D, EDO, GOL, EOH and PDO as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1MR3 OCA].
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=G3D:GUANOSINE-3-MONOPHOSPHATE-5-DIPHOSPHATE'>G3D</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PDO:1,3-PROPANDIOL'>PDO</scene></td></tr>
-
==Reference==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mr3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mr3 OCA], [https://pdbe.org/1mr3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mr3 RCSB], [https://www.ebi.ac.uk/pdbsum/1mr3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mr3 ProSAT]</span></td></tr>
-
Structures of yeast ARF2 and ARL1: distinct roles for the N terminus in the structure and function of ARF family GTPases., Amor JC, Horton JR, Zhu X, Wang Y, Sullards C, Ringe D, Cheng X, Kahn RA, J Biol Chem. 2001 Nov 9;276(45):42477-84. Epub 2001 Sep 4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11535602 11535602]
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ARF2_YEAST ARF2_YEAST] GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mr/1mr3_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mr3 ConSurf].
 +
<div style="clear:both"></div>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
-
[[Category: Single protein]]
+
[[Category: Amor J-C]]
-
[[Category: Amor, J.C.]]
+
[[Category: Cheng X]]
-
[[Category: Cheng, X.]]
+
[[Category: Horton JR]]
-
[[Category: Horton, J.R.]]
+
[[Category: Kahn RA]]
-
[[Category: Kahn, R.A.]]
+
[[Category: Ringe D]]
-
[[Category: Ringe, D.]]
+
[[Category: Sullards C]]
-
[[Category: Sullards, C.]]
+
[[Category: Wang Y]]
-
[[Category: Wang, Y.]]
+
[[Category: Zhu X]]
-
[[Category: Zhu, X.]]
+
-
[[Category: EDO]]
+
-
[[Category: EOH]]
+
-
[[Category: G3D]]
+
-
[[Category: GOL]]
+
-
[[Category: MG]]
+
-
[[Category: PDO]]
+
-
[[Category: gdp-3'phosphate]]
+
-
[[Category: gtp-binding]]
+
-
[[Category: signal transduction]]
+
-
[[Category: small gtpase]]
+
-
 
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 21:38:41 2007''
+

Current revision

Saccharomyces cerevisiae ADP-ribosylation Factor 2 (ScArf2) complexed with GDP-3'P at 1.6A resolution

PDB ID 1mr3

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1mr3"
Personal tools