2bec

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{{Seed}}
 
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[[Image:2bec.png|left|200px]]
 
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==Crystal structure of CHP2 in complex with its binding region in NHE1 and insights into the mechanism of pH regulation==
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The line below this paragraph, containing "STRUCTURE_2bec", creates the "Structure Box" on the page.
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<StructureSection load='2bec' size='340' side='right'caption='[[2bec]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2bec]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BEC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BEC FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YT3:YTTRIUM+(III)+ION'>YT3</scene></td></tr>
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{{STRUCTURE_2bec| PDB=2bec | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bec OCA], [https://pdbe.org/2bec PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bec RCSB], [https://www.ebi.ac.uk/pdbsum/2bec PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bec ProSAT]</span></td></tr>
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</table>
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===Crystal structure of CHP2 in complex with its binding region in NHE1 and insights into the mechanism of pH regulation===
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== Function ==
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[https://www.uniprot.org/uniprot/CHP2_HUMAN CHP2_HUMAN] Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus.<ref>PMID:12226101</ref> <ref>PMID:18815128</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 16710297 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/be/2bec_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_16710297}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2BEC is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BEC OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bec ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Crystal structure of CHP2 complexed with NHE1-cytosolic region and an implication for pH regulation., Ammar YB, Takeda S, Hisamitsu T, Mori H, Wakabayashi S, EMBO J. 2006 Jun 7;25(11):2315-25. Epub 2006 May 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16710297 16710297]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Ammar, Y Ben.]]
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[[Category: Ben Ammar Y]]
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[[Category: Hisamitsu, T.]]
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[[Category: Hisamitsu T]]
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[[Category: Mori, H.]]
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[[Category: Mori H]]
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[[Category: Takeda, S.]]
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[[Category: Takeda S]]
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[[Category: Wakabayashi, S.]]
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[[Category: Wakabayashi S]]
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[[Category: Calcineurin-homologous protein]]
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[[Category: Calcium-binding protein]]
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[[Category: Nhe1 regulating protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:54:24 2008''
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Current revision

Crystal structure of CHP2 in complex with its binding region in NHE1 and insights into the mechanism of pH regulation

PDB ID 2bec

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