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2efj

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{{Seed}}
 
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[[Image:2efj.png|left|200px]]
 
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<!--
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==The structure of 1,7 dimethylxanthine methyltransferase==
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The line below this paragraph, containing "STRUCTURE_2efj", creates the "Structure Box" on the page.
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<StructureSection load='2efj' size='340' side='right'caption='[[2efj]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2efj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Coffea_canephora Coffea canephora]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EFJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EFJ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=37T:THEOBROMINE'>37T</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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{{STRUCTURE_2efj| PDB=2efj | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2efj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2efj OCA], [https://pdbe.org/2efj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2efj RCSB], [https://www.ebi.ac.uk/pdbsum/2efj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2efj ProSAT]</span></td></tr>
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</table>
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===The structure of 1,7 dimethylxanthine methyltransferase===
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== Function ==
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[https://www.uniprot.org/uniprot/DXMT1_COFCA DXMT1_COFCA] Involved in the biosynthesis of caffeine. Catalyzes the conversion of 7-methylxanthine to theobromine and of theobromine to caffeine, but no sequential conversion of 7-methylxanthine to caffeine was detected.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_17434991}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 17434991 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ef/2efj_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_17434991}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2EFJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Coffea_canephora Coffea canephora]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EFJ OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2efj ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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The structure of two N-methyltransferases from the caffeine biosynthetic pathway., McCarthy AA, McCarthy JG, Plant Physiol. 2007 Jun;144(2):879-89. Epub 2007 Apr 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17434991 17434991]
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</StructureSection>
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Cloning, expression, crystallization and preliminary X-ray analysis of the XMT and DXMT N-methyltransferases from Coffea canephora (robusta)., McCarthy AA, Biget L, Lin C, Petiard V, Tanksley SD, McCarthy JG, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Apr 1;63(Pt, 4):304-7. Epub 2007 Mar 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17401201 17401201]
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[[Category: Coffea canephora]]
[[Category: Coffea canephora]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: McCarthy, A A.]]
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[[Category: McCarthy AA]]
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[[Category: McCarthy, J G.]]
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[[Category: McCarthy JG]]
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[[Category: Sah]]
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[[Category: Sam-dependant methyltransferase]]
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[[Category: Theobromine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:56:35 2008''
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Current revision

The structure of 1,7 dimethylxanthine methyltransferase

PDB ID 2efj

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