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1otj

From Proteopedia

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{{Seed}}
 
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[[Image:1otj.png|left|200px]]
 
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==Crystal structure of APO (iron-free) TauD==
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The line below this paragraph, containing "STRUCTURE_1otj", creates the "Structure Box" on the page.
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<StructureSection load='1otj' size='340' side='right'caption='[[1otj]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1otj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OTJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OTJ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TAU:2-AMINOETHANESULFONIC+ACID'>TAU</scene></td></tr>
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{{STRUCTURE_1otj| PDB=1otj | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1otj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1otj OCA], [https://pdbe.org/1otj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1otj RCSB], [https://www.ebi.ac.uk/pdbsum/1otj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1otj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TAUD_ECOLI TAUD_ECOLI] Catalyzes the conversion of taurine and alpha ketoglutarate to sulfite, aminoacetaldehyde and succinate. Required for the utilization of taurine (2-aminoethanesulfonic acid) as an alternative sulfur source. Pentane-sulfonic acid, 3-(N-morpholino)propanesulfonic acid and 1,3-dioxo-2-isoindolineethanesulfonic acid are also substrates for this enzyme.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ot/1otj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1otj ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of APO (iron-free) TauD===
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==See Also==
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*[[Dioxygenase 3D structures|Dioxygenase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_12741810}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12741810 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12741810}}
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==About this Structure==
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1OTJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OTJ OCA].
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==Reference==
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Substrate-induced conformational changes in Escherichia coli taurine/alpha-ketoglutarate dioxygenase and insight into the oligomeric structure., O'Brien JR, Schuller DJ, Yang VS, Dillard BD, Lanzilotta WN, Biochemistry. 2003 May 20;42(19):5547-54. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12741810 12741810]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Taurine dioxygenase]]
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[[Category: Dillard BD]]
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[[Category: Brien, J R.O.]]
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[[Category: Lanzilotta WN]]
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[[Category: Dillard, B D.]]
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[[Category: O'Brien JR]]
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[[Category: Lanzilotta, W N.]]
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[[Category: Schuller DJ]]
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[[Category: Schuller, D J.]]
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[[Category: Yang VS]]
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[[Category: Yang, V S.]]
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[[Category: Alpha ketoglutarate-dependent dioxygenase]]
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[[Category: Jelly roll motif]]
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[[Category: Taurine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:02:56 2008''
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Current revision

Crystal structure of APO (iron-free) TauD

PDB ID 1otj

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