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1orc

From Proteopedia

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{{Seed}}
 
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[[Image:1orc.png|left|200px]]
 
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==CRO REPRESSOR INSERTION MUTANT K56-[DGEVK]==
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The line below this paragraph, containing "STRUCTURE_1orc", creates the "Structure Box" on the page.
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<StructureSection load='1orc' size='340' side='right'caption='[[1orc]], [[Resolution|resolution]] 1.54&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1orc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_Lambda Escherichia virus Lambda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ORC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ORC FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.54&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1orc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1orc OCA], [https://pdbe.org/1orc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1orc RCSB], [https://www.ebi.ac.uk/pdbsum/1orc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1orc ProSAT]</span></td></tr>
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{{STRUCTURE_1orc| PDB=1orc | SCENE= }}
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</table>
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== Function ==
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===CRO REPRESSOR INSERTION MUTANT K56-[DGEVK]===
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[https://www.uniprot.org/uniprot/RCRO_LAMBD RCRO_LAMBD] Cro represses genes normally expressed in early phage development and is necessary for the late stage of lytic growth. It does this by binding to the OL and OR operators regions normally used by the repressor protein for lysogenic maintenance.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_8547253}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 8547253 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/or/1orc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_8547253}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1orc ConSurf].
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1ORC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_lambda Enterobacteria phage lambda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ORC OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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High-resolution structure of an engineered Cro monomer shows changes in conformation relative to the native dimer., Albright RA, Mossing MC, Matthews BW, Biochemistry. 1996 Jan 23;35(3):735-42. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8547253 8547253]
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[[Category: Escherichia virus Lambda]]
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[[Category: Enterobacteria phage lambda]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Albright RA]]
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[[Category: Albright, R A.]]
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[[Category: Matthews BW]]
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[[Category: Matthews, B W.]]
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[[Category: Mossing MC]]
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[[Category: Mossing, M C.]]
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[[Category: Gene regulating protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:26:25 2008''
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Current revision

CRO REPRESSOR INSERTION MUTANT K56-[DGEVK]

PDB ID 1orc

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