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1p4a

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{{Seed}}
 
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[[Image:1p4a.png|left|200px]]
 
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<!--
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==Crystal Structure of the PurR complexed with cPRPP==
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The line below this paragraph, containing "STRUCTURE_1p4a", creates the "Structure Box" on the page.
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<StructureSection load='1p4a' size='340' side='right'caption='[[1p4a]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1p4a]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P4A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P4A FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.22&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCP:1-ALPHA-PYROPHOSPHORYL-2-ALPHA,3-ALPHA-DIHYDROXY-4-BETA-CYCLOPENTANE-METHANOL-5-PHOSPHATE'>PCP</scene></td></tr>
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{{STRUCTURE_1p4a| PDB=1p4a | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p4a OCA], [https://pdbe.org/1p4a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p4a RCSB], [https://www.ebi.ac.uk/pdbsum/1p4a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p4a ProSAT]</span></td></tr>
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</table>
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===Crystal Structure of the PurR complexed with cPRPP===
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== Function ==
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[https://www.uniprot.org/uniprot/PURR_BACSU PURR_BACSU] Controls the transcription of the pur operon for purine biosynthetic genes, binds to the control region of the operon. DNA binding is inhibited by 5-phosphoribosyl 1-pyrophosphate.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 12837784 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p4/1p4a_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_12837784}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1P4A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P4A OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p4a ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Functional dissection of the Bacillus subtilis pur operator site., Bera AK, Zhu J, Zalkin H, Smith JL, J Bacteriol. 2003 Jul;185(14):4099-109. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12837784 12837784]
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</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bera, A K.]]
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[[Category: Bera AK]]
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[[Category: Smith, J L.]]
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[[Category: Smith JL]]
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[[Category: Zalkin, H.]]
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[[Category: Zalkin H]]
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[[Category: Zhu, J.]]
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[[Category: Zhu J]]
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[[Category: Transcription]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:28:33 2008''
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Current revision

Crystal Structure of the PurR complexed with cPRPP

PDB ID 1p4a

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