1tpv

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{{Seed}}
 
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[[Image:1tpv.png|left|200px]]
 
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==S96P CHANGE IS A SECOND-SITE SUPPRESSOR FOR H95N SLUGGISH MUTANT TRIOSEPHOSPHATE ISOMERASE==
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The line below this paragraph, containing "STRUCTURE_1tpv", creates the "Structure Box" on the page.
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<StructureSection load='1tpv' size='340' side='right'caption='[[1tpv]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1tpv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TPV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TPV FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGH:PHOSPHOGLYCOLOHYDROXAMIC+ACID'>PGH</scene></td></tr>
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{{STRUCTURE_1tpv| PDB=1tpv | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tpv OCA], [https://pdbe.org/1tpv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tpv RCSB], [https://www.ebi.ac.uk/pdbsum/1tpv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tpv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TPIS_CHICK TPIS_CHICK]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tp/1tpv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tpv ConSurf].
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<div style="clear:both"></div>
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===S96P CHANGE IS A SECOND-SITE SUPPRESSOR FOR H95N SLUGGISH MUTANT TRIOSEPHOSPHATE ISOMERASE===
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==See Also==
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*[[Triose phosphate isomerase 3D structures|Triose phosphate isomerase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_8952501}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8952501 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8952501}}
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==About this Structure==
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1TPV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TPV OCA].
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==Reference==
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The structural basis for pseudoreversion of the H95N lesion by the secondary S96P mutation in triosephosphate isomerase., Komives EA, Lougheed JC, Zhang Z, Sugio S, Narayana N, Xuong NH, Petsko GA, Ringe D, Biochemistry. 1996 Dec 3;35(48):15474-84. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8952501 8952501]
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[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Triose-phosphate isomerase]]
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[[Category: Knowles JR]]
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[[Category: Knowles, J R.]]
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[[Category: Komives EA]]
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[[Category: Komives, E A.]]
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[[Category: Liu KD]]
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[[Category: Liu, K D.]]
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[[Category: Narayana N]]
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[[Category: Narayana, N.]]
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[[Category: Petsko GA]]
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[[Category: Petsko, G A.]]
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[[Category: Ringe D]]
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[[Category: Ringe, D.]]
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[[Category: Stock AM]]
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[[Category: Stock, A M.]]
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[[Category: Sugio S]]
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[[Category: Sugio, S.]]
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[[Category: Xuong NgH]]
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[[Category: Xuong, Ng H.]]
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[[Category: Zhang Z]]
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[[Category: Zhang, Z.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:37:41 2008''
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Current revision

S96P CHANGE IS A SECOND-SITE SUPPRESSOR FOR H95N SLUGGISH MUTANT TRIOSEPHOSPHATE ISOMERASE

PDB ID 1tpv

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