2oox

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{{Seed}}
 
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[[Image:2oox.png|left|200px]]
 
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==Crystal structure of the adenylate sensor from AMP-activated protein kinase complexed with AMP==
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The line below this paragraph, containing "STRUCTURE_2oox", creates the "Structure Box" on the page.
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<StructureSection load='2oox' size='340' side='right'caption='[[2oox]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2oox]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OOX FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
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{{STRUCTURE_2oox| PDB=2oox | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oox OCA], [https://pdbe.org/2oox PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oox RCSB], [https://www.ebi.ac.uk/pdbsum/2oox PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oox ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SNF1_SCHPO SNF1_SCHPO]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oo/2oox_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2oox ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The 5'-AMP (adenosine monophosphate)-activated protein kinase (AMPK) coordinates metabolic function with energy availability by responding to changes in intracellular ATP (adenosine triphosphate) and AMP concentrations. Here, we report crystal structures at 2.9 and 2.6 A resolution for ATP- and AMP-bound forms of a core alphabetagamma adenylate-binding domain from the fission yeast AMPK homolog. ATP and AMP bind competitively to a single site in the gamma subunit, with their respective phosphate groups positioned near function-impairing mutants. Unexpectedly, ATP binds without counterions, amplifying its electrostatic effects on a critical regulatory region where all three subunits converge.
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===Crystal structure of the adenylate sensor from AMP-activated protein kinase complexed with AMP===
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Crystal structures of the adenylate sensor from fission yeast AMP-activated protein kinase.,Townley R, Shapiro L Science. 2007 Mar 23;315(5819):1726-9. Epub 2007 Feb 8. PMID:17289942<ref>PMID:17289942</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17289942}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2oox" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17289942 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17289942}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2OOX is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOX OCA].
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==Reference==
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Crystal structures of the adenylate sensor from fission yeast AMP-activated protein kinase., Townley R, Shapiro L, Science. 2007 Mar 23;315(5819):1726-9. Epub 2007 Feb 8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17289942 17289942]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Protein complex]]
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[[Category: Schizosaccharomyces pombe]]
[[Category: Schizosaccharomyces pombe]]
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[[Category: Shapiro, L.]]
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[[Category: Shapiro L]]
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[[Category: Townley, R.]]
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[[Category: Townley R]]
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[[Category: Amp]]
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[[Category: Ampk]]
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[[Category: Crystal structure]]
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[[Category: Kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:42:44 2008''
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Current revision

Crystal structure of the adenylate sensor from AMP-activated protein kinase complexed with AMP

PDB ID 2oox

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