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1vtk

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{{Seed}}
 
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[[Image:1vtk.png|left|200px]]
 
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==THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE 1 IN COMPLEX WITH ADP AND DEOXYTHYMIDINE-MONOPHOSPHATE==
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The line below this paragraph, containing "STRUCTURE_1vtk", creates the "Structure Box" on the page.
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<StructureSection load='1vtk' size='340' side='right'caption='[[1vtk]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1vtk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_F Human alphaherpesvirus 1 strain F]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VTK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VTK FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=TMP:THYMIDINE-5-PHOSPHATE'>TMP</scene></td></tr>
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{{STRUCTURE_1vtk| PDB=1vtk | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vtk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vtk OCA], [https://pdbe.org/1vtk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vtk RCSB], [https://www.ebi.ac.uk/pdbsum/1vtk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vtk ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KITH_HHV11 KITH_HHV11] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vt/1vtk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vtk ConSurf].
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<div style="clear:both"></div>
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===THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE 1 IN COMPLEX WITH ADP AND DEOXYTHYMIDINE-MONOPHOSPHATE===
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==See Also==
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*[[Thymidine kinase 3D structures|Thymidine kinase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_9336833}}, adds the Publication Abstract to the page
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[[Category: Human alphaherpesvirus 1 strain F]]
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(as it appears on PubMed at http://www.pubmed.gov), where 9336833 is the PubMed ID number.
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[[Category: Large Structures]]
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[[Category: Schulz GE]]
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{{ABSTRACT_PUBMED_9336833}}
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[[Category: Wild K]]
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==About this Structure==
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1VTK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_1 Human herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VTK OCA].
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==Reference==
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The structures of thymidine kinase from herpes simplex virus type 1 in complex with substrates and a substrate analogue., Wild K, Bohner T, Folkers G, Schulz GE, Protein Sci. 1997 Oct;6(10):2097-106. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9336833 9336833]
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[[Category: Human herpesvirus 1]]
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[[Category: Single protein]]
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[[Category: Thymidine kinase]]
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[[Category: Schulz, G E.]]
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[[Category: Wild, K.]]
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[[Category: Additional thymidylate kinase activity]]
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[[Category: Key enzyme in thymidine salvage pathway]]
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[[Category: Target for anti-herpes viral drug]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:45:41 2008''
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Current revision

THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE 1 IN COMPLEX WITH ADP AND DEOXYTHYMIDINE-MONOPHOSPHATE

PDB ID 1vtk

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