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1gny

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(New page: 200px<br /> <applet load="1gny" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gny, resolution 1.63&Aring;" /> '''XYLAN-BINDING MODUL...)
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[[Image:1gny.gif|left|200px]]<br />
 
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<applet load="1gny" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1gny, resolution 1.63&Aring;" />
 
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'''XYLAN-BINDING MODULE CBM15'''<br />
 
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==Overview==
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==xylan-binding module CBM15==
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The recycling of photosynthetically fixed carbon by the action of, microbial glycoside hydrolases is a key biological process. The consortium, of degradative enzymes involved in this process frequently display, catalytic modules appended to one or more noncatalytic, carbohydrate-binding modules (CBMs). CBMs play a central role in the, optimization of the catalytic activity of plant cell wall hydrolases, through their binding to specific plant structural polysaccharides., Despite their pivotal role in the biodegradation of plant biomass, the, mechanism by which these proteins recognize their target ligands is, unclear. This report describes the structure of a xylan-binding CBM, (CBM15) in complex with its ligand. This module, derived from Pseudomonas, cellulosa xylanase Xyn10C, binds to ... [[http://ispc.weizmann.ac.il/pmbin/getpm?11598143 (full description)]]
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<StructureSection load='1gny' size='340' side='right'caption='[[1gny]], [[Resolution|resolution]] 1.63&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1gny]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cellvibrio_japonicus Cellvibrio japonicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GNY FirstGlance]. <br>
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1GNY is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Pseudomonas_cellulosa Pseudomonas cellulosa]] with NA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.8 3.2.1.8]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GNY OCA]].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.63&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=XYP:BETA-D-XYLOPYRANOSE'>XYP</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gny OCA], [https://pdbe.org/1gny PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gny RCSB], [https://www.ebi.ac.uk/pdbsum/1gny PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gny ProSAT]</span></td></tr>
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Structure of a family 15 carbohydrate-binding module in complex with xylopentaose. Evidence that xylan binds in an approximate 3-fold helical conformation., Szabo L, Jamal S, Xie H, Charnock SJ, Bolam DN, Gilbert HJ, Davies GJ, J Biol Chem. 2001 Dec 28;276(52):49061-5. Epub 2001 Oct 11. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11598143 11598143]
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</table>
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[[Category: Pseudomonas cellulosa]]
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== Function ==
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[[Category: Single protein]]
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[https://www.uniprot.org/uniprot/XY10C_CELJA XY10C_CELJA] Endo-acting xylanase which specifically cleaves internal linkages on the xylan backbone, releasing xylooligosaccharides. Is able to hydrolyze oat spelt xylan, the arabinoxylans from wheat and rye, and glucuronoxylan. Also displays very low activity against xylooligosaccharides. During the xylan degradation process, Xyn10C may act on the soluble xylans and long xylooligosaccharides products released by the secreted xylanases Xyn11A, Xyn11B and Xyn10A.<ref>PMID:14670951</ref> <ref>PMID:7492333</ref>
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[[Category: Bolam, D.N.]]
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== References ==
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[[Category: Charnock, S.J.]]
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<references/>
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[[Category: Davies, G.J.]]
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__TOC__
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[[Category: Gilbert, H.J.]]
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</StructureSection>
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[[Category: Jamal, S.]]
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[[Category: Cellvibrio japonicus]]
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[[Category: Szabo, S.]]
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[[Category: Large Structures]]
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[[Category: Xie, H.]]
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[[Category: Bolam DN]]
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[[Category: NA]]
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[[Category: Charnock SJ]]
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[[Category: carbohydrate-binding module]]
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[[Category: Davies GJ]]
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[[Category: catalysis]]
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[[Category: Gilbert HJ]]
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[[Category: xylan]]
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[[Category: Jamal S]]
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[[Category: xylanase]]
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[[Category: Szabo S]]
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[[Category: xylooligosaccharide]]
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[[Category: Xie H]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 20:31:58 2007''
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Current revision

xylan-binding module CBM15

PDB ID 1gny

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