1n6n

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:46, 10 April 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1n6n.png|left|200px]]
 
-
<!--
+
==Crystal Structure of Human Rab5a A30R mutant complex with GppNHp==
-
The line below this paragraph, containing "STRUCTURE_1n6n", creates the "Structure Box" on the page.
+
<StructureSection load='1n6n' size='340' side='right'caption='[[1n6n]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1n6n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N6N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N6N FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-
{{STRUCTURE_1n6n| PDB=1n6n | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n6n OCA], [https://pdbe.org/1n6n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n6n RCSB], [https://www.ebi.ac.uk/pdbsum/1n6n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n6n ProSAT]</span></td></tr>
-
 
+
</table>
-
===Crystal Structure of Human Rab5a A30R mutant complex with GppNHp===
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/RAB5A_HUMAN RAB5A_HUMAN] Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension.<ref>PMID:14978216</ref>
-
 
+
== Evolutionary Conservation ==
-
<!--
+
[[Image:Consurf_key_small.gif|200px|right]]
-
The line below this paragraph, {{ABSTRACT_PUBMED_12433916}}, adds the Publication Abstract to the page
+
Check<jmol>
-
(as it appears on PubMed at http://www.pubmed.gov), where 12433916 is the PubMed ID number.
+
<jmolCheckbox>
-
-->
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n6/1n6n_consurf.spt"</scriptWhenChecked>
-
{{ABSTRACT_PUBMED_12433916}}
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
 
+
<text>to colour the structure by Evolutionary Conservation</text>
-
==About this Structure==
+
</jmolCheckbox>
-
1N6N is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N6N OCA].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n6n ConSurf].
-
 
+
<div style="clear:both"></div>
-
==Reference==
+
== References ==
-
High resolution crystal structures of human Rab5a and five mutants with substitutions in the catalytically important phosphate-binding loop., Zhu G, Liu J, Terzyan S, Zhai P, Li G, Zhang XC, J Biol Chem. 2003 Jan 24;278(4):2452-60. Epub 2002 Nov 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12433916 12433916]
+
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Li, G.]]
+
[[Category: Li G]]
-
[[Category: Liu, J.]]
+
[[Category: Liu J]]
-
[[Category: Terzyan, S.]]
+
[[Category: Terzyan S]]
-
[[Category: Zhai, P.]]
+
[[Category: Zhai P]]
-
[[Category: Zhang, X C.]]
+
[[Category: Zhang XC]]
-
[[Category: Zhu, G.]]
+
[[Category: Zhu G]]
-
[[Category: Gtpase]]
+
-
[[Category: Rab]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:53:36 2008''
+

Current revision

Crystal Structure of Human Rab5a A30R mutant complex with GppNHp

PDB ID 1n6n

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1n6n"
Personal tools