2bw3

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{{Seed}}
 
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[[Image:2bw3.png|left|200px]]
 
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==Three-dimensional structure of the Hermes DNA transposase==
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The line below this paragraph, containing "STRUCTURE_2bw3", creates the "Structure Box" on the page.
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<StructureSection load='2bw3' size='340' side='right'caption='[[2bw3]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2bw3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Musca_domestica Musca domestica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BW3 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_2bw3| PDB=2bw3 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bw3 OCA], [https://pdbe.org/2bw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bw3 RCSB], [https://www.ebi.ac.uk/pdbsum/2bw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bw3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q25438_MUSDO Q25438_MUSDO]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bw/2bw3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bw3 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Mobile elements and their inactive remnants account for large proportions of most eukaryotic genomes, where they have had central roles in genome evolution. Over 50 years ago, McClintock reported a form of stress-induced genome instability in maize in which discrete DNA segments move between chromosomal locations. Our current mechanistic understanding of enzymes catalyzing transposition is largely limited to prokaryotic transposases. The Hermes transposon from the housefly is part of the eukaryotic hAT superfamily that includes hobo from Drosophila, McClintock's maize Activator and Tam3 from snapdragon. We report here the three-dimensional structure of a functionally active form of the transposase from Hermes at 2.1-A resolution. The Hermes protein has some structural features of prokaryotic transposases, including a domain with a retroviral integrase fold. However, this domain is disrupted by the insertion of an additional domain. Finally, transposition is observed only when Hermes assembles into a hexamer.
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===THREE-DIMENSIONAL STRUCTURE OF THE HERMES DNA TRANSPOSASE===
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Molecular architecture of a eukaryotic DNA transposase.,Hickman AB, Perez ZN, Zhou L, Musingarimi P, Ghirlando R, Hinshaw JE, Craig NL, Dyda F Nat Struct Mol Biol. 2005 Aug;12(8):715-21. Epub 2005 Jul 24. PMID:16041385<ref>PMID:16041385</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2bw3" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_16041385}}, adds the Publication Abstract to the page
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*[[Transposase 3D structures|Transposase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 16041385 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16041385}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2BW3 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Musca_domestica Musca domestica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BW3 OCA].
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==Reference==
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Molecular architecture of a eukaryotic DNA transposase., Hickman AB, Perez ZN, Zhou L, Musingarimi P, Ghirlando R, Hinshaw JE, Craig NL, Dyda F, Nat Struct Mol Biol. 2005 Aug;12(8):715-21. Epub 2005 Jul 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16041385 16041385]
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[[Category: Musca domestica]]
[[Category: Musca domestica]]
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[[Category: Protein complex]]
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[[Category: Craig NL]]
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[[Category: Craig, N L.]]
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[[Category: Dyda F]]
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[[Category: Dyda, F.]]
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[[Category: Ghirlando R]]
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[[Category: Ghirlando, R.]]
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[[Category: Hickman AB]]
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[[Category: Hickman, A B.]]
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[[Category: Hinshaw JE]]
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[[Category: Hinshaw, J E.]]
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[[Category: Musingarimi P]]
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[[Category: Musingarimi, P.]]
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[[Category: Perez ZN]]
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[[Category: Perez, Z N.]]
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[[Category: Zhou L]]
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[[Category: Zhou, L.]]
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[[Category: Dna recombination]]
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[[Category: Transposition]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:54:30 2008''
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Current revision

Three-dimensional structure of the Hermes DNA transposase

PDB ID 2bw3

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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