2g46

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{{Seed}}
 
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[[Image:2g46.png|left|200px]]
 
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==structure of vSET in complex with meK27 H3 Pept. and cofactor product SAH==
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The line below this paragraph, containing "STRUCTURE_2g46", creates the "Structure Box" on the page.
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<StructureSection load='2g46' size='340' side='right'caption='[[2g46]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2g46]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Chlorella_pbcv-1_virus Chlorella pbcv-1 virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G46 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G46 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene></td></tr>
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{{STRUCTURE_2g46| PDB=2g46 | SCENE= }}
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">A612L ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10506 Chlorella PBCV-1 virus])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g46 OCA], [https://pdbe.org/2g46 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g46 RCSB], [https://www.ebi.ac.uk/pdbsum/2g46 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g46 ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g4/2g46_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g46 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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SET domain lysine methyltransferases are known to catalyze site and state-specific methylation of lysine residues in histones that is fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. Here we report the three-dimensional solution structure of the SET domain histone lysine methyltransferase (vSET) from Paramecium bursaria chlorella virus 1 bound to cofactor S-adenosyl-L-homocysteine and a histone H3 peptide containing mono-methylated lysine 27. The dimeric structure, mimicking an enzyme/cofactor/substrate complex, yields the structural basis of the substrate specificity and methylation multiplicity of the enzyme. Our results from mutagenesis and enzyme kinetics analyses argue that a general base mechanism is less likely for lysine methylation by SET domains; and that the only invariant active site residue tyrosine 105 in vSET facilitates methyl transfer from cofactor to the substrate lysine by aligning intermolecular interactions in the lysine access channel of the enzyme.
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===structure of vSET in complex with meK27 H3 Pept. and cofactor product SAH===
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Structural insights of the specificity and catalysis of a viral histone H3 lysine 27 methyltransferase.,Qian C, Wang X, Manzur K, Sachchidanand, Farooq A, Zeng L, Wang R, Zhou MM J Mol Biol. 2006 May 26;359(1):86-96. Epub 2006 Mar 20. PMID:16603186<ref>PMID:16603186</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2g46" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_16603186}}, adds the Publication Abstract to the page
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*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 16603186 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16603186}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Chlorella pbcv-1 virus]]
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2G46 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Paramecium_bursaria_chlorella_virus_1 Paramecium bursaria chlorella virus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G46 OCA].
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[[Category: Large Structures]]
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[[Category: Qian, C M]]
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==Reference==
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[[Category: Zheng, L]]
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Structural insights of the specificity and catalysis of a viral histone H3 lysine 27 methyltransferase., Qian C, Wang X, Manzur K, Sachchidanand, Farooq A, Zeng L, Wang R, Zhou MM, J Mol Biol. 2006 May 26;359(1):86-96. Epub 2006 Mar 20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16603186 16603186]
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[[Category: Zhou, M M]]
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[[Category: Paramecium bursaria chlorella virus 1]]
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[[Category: Single protein]]
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[[Category: Qian, C M.]]
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[[Category: Zheng, L.]]
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[[Category: Zhou, M M.]]
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[[Category: Hsitone methyltransferase]]
[[Category: Hsitone methyltransferase]]
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[[Category: Nmr]]
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[[Category: Transferase]]
[[Category: Vset structure]]
[[Category: Vset structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:10:51 2008''
 

Current revision

structure of vSET in complex with meK27 H3 Pept. and cofactor product SAH

PDB ID 2g46

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