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1myu

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(New page: 200px<br /><applet load="1myu" size="450" color="white" frame="true" align="right" spinBox="true" caption="1myu" /> '''Lipid induced conformation of the tachykinin...)
Current revision (06:32, 1 May 2024) (edit) (undo)
 
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[[Image:1myu.gif|left|200px]]<br /><applet load="1myu" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1myu" />
 
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'''Lipid induced conformation of the tachykinin peptide Kassinin'''<br />
 
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==Overview==
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==Lipid induced conformation of the tachykinin peptide Kassinin==
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Both the aqueous and lipid-induced structure of Kassinin, a dodecapeptide, of amphibian origin, has been studied by two-dimensional proton nuclear, magnetic resonance (2D 1H-NMR) spectroscopy and distance geometry, calculations. Unambiguous NMR assignments of protons have been made with, the aid of correlation spectroscopy (DQF-COSY and TOCSY) experiments and, nuclear Overhauser effect spectroscopy (NOESY and ROESY) experiments. The, distance constraints obtained from the NMR data have been utilized in a, distance geometry algorithm to generate a family of structures, which have, been refined using restrained energy minimization and dynamics. These data, show that, while in water Kassinin prefers to be in an extended chain, conformation, in the presence of perdeuterated dodecylphosphocholine (DPC), micelles, a membrane model system, helical conformation is induced in the, central core and C-terminal region (K4-M12) of the peptide. N-terminus, though less defined also displays some degree of order and a possible turn, structure. The conformation adopted by Kassinin in the presence of DPC, micelles is consistent with the structural motif typical of neurokinin-1, selective agonists and with that reported for Eledoisin in hydrophobic, environment.
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<StructureSection load='1myu' size='340' side='right'caption='[[1myu]]' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1myu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Kassina_senegalensis Kassina senegalensis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MYU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MYU FirstGlance]. <br>
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1MYU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1MYU OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1myu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1myu OCA], [https://pdbe.org/1myu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1myu RCSB], [https://www.ebi.ac.uk/pdbsum/1myu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1myu ProSAT]</span></td></tr>
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==Reference==
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</table>
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Lipid induced conformation of the tachykinin peptide Kassinin., Grace RC, Lynn AM, Cowsik SM, J Biomol Struct Dyn. 2001 Feb;18(4):611-21, 623-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11245256 11245256]
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== Function ==
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[[Category: Single protein]]
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[https://www.uniprot.org/uniprot/TKN_KASSE TKN_KASSE] Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
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[[Category: Cowsik, S.M.]]
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__TOC__
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[[Category: Grace, R.C.]]
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</StructureSection>
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[[Category: Lynn, A.M.]]
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[[Category: Kassina senegalensis]]
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[[Category: 3-10 helix]]
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[[Category: Large Structures]]
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[[Category: dpc micelles]]
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[[Category: Cowsik SM]]
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[[Category: helical core]]
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[[Category: Grace RC]]
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[[Category: lipid induced conformation]]
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[[Category: Lynn AM]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 21:49:09 2007''
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Current revision

Lipid induced conformation of the tachykinin peptide Kassinin

PDB ID 1myu

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