1xqj

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{{Seed}}
 
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[[Image:1xqj.png|left|200px]]
 
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==3.10 A Crystal structure of maspin, space group I 4 2 2==
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The line below this paragraph, containing "STRUCTURE_1xqj", creates the "Structure Box" on the page.
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<StructureSection load='1xqj' size='340' side='right'caption='[[1xqj]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1xqj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XQJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XQJ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xqj OCA], [https://pdbe.org/1xqj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xqj RCSB], [https://www.ebi.ac.uk/pdbsum/1xqj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xqj ProSAT]</span></td></tr>
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{{STRUCTURE_1xqj| PDB=1xqj | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SPB5_HUMAN SPB5_HUMAN] Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xq/1xqj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xqj ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Maspin, a member of the serpin superfamily, has tumor suppressing activity against breast and prostate cancer. Maspin inhibits tumor growth by blocking cell invasion, and its reactive center loop (RCL) is thought to mediate this activity. To understand this function on the molecular level, we have solved the three-dimensional structure of Maspin to 3.1 A resolution. The molecular structure shows the characteristic features of the serpin fold, but the RCL of Maspin is unique in length, composition, and placement. Although the RCL of Maspin is accessible and cleavable by some proteinases, it functions in the uncleaved, constrained conformation observed here. These structural results will contribute to our understanding of the mechanism by which Maspin suppresses tumors.
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===3.10 A Crystal structure of maspin, space group I 4 2 2===
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Crystal structure of human maspin, a serpin with antitumor properties: reactive center loop of maspin is exposed but constrained.,Al-Ayyoubi M, Gettins PG, Volz K J Biol Chem. 2004 Dec 31;279(53):55540-4. Epub 2004 Oct 22. PMID:15501821<ref>PMID:15501821</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1xqj" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_15501821}}, adds the Publication Abstract to the page
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*[[Serpin 3D structures|Serpin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15501821 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15501821}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1XQJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XQJ OCA].
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==Reference==
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Crystal structure of human maspin, a serpin with antitumor properties: reactive center loop of maspin is exposed but constrained., Al-Ayyoubi M, Gettins PG, Volz K, J Biol Chem. 2004 Dec 31;279(53):55540-4. Epub 2004 Oct 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15501821 15501821]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Al-Ayyoubi, M.]]
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[[Category: Al-Ayyoubi M]]
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[[Category: Gettins, P G.]]
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[[Category: Gettins PG]]
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[[Category: Volz, K.]]
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[[Category: Volz K]]
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[[Category: Maspin]]
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[[Category: Serpin]]
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[[Category: Tumor suppression]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:17:14 2008''
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Current revision

3.10 A Crystal structure of maspin, space group I 4 2 2

PDB ID 1xqj

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