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2fm2

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{{Seed}}
 
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[[Image:2fm2.png|left|200px]]
 
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==HCV NS3-4A protease domain complexed with a ketoamide inhibitor, SCH446211==
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The line below this paragraph, containing "STRUCTURE_2fm2", creates the "Structure Box" on the page.
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<StructureSection load='2fm2' size='340' side='right'caption='[[2fm2]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2fm2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepacivirus_C Hepacivirus C] and [https://en.wikipedia.org/wiki/Hepatitis_C_virus_genotype_1a Hepatitis C virus genotype 1a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FM2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FM2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3BC:TERT-BUTYL+[(1S)-1-({(1R,2S,5S)-2-[(3S,10S)-3-(CYCLOPROPYLMETHYL)-12-METHYL-4,5,8,11-TETRAOXO-10-PHENYL-2,6,9,12-TETRAAZATRIDECAN-1+-OYL]-6,6-DIMETHYL-3-AZABICYCLO[3.1.0]HEX-3-YL}CARBONYL)-2,2-DIMETHYLPROPYL]CARBAMATE'>3BC</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2fm2| PDB=2fm2 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fm2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fm2 OCA], [https://pdbe.org/2fm2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fm2 RCSB], [https://www.ebi.ac.uk/pdbsum/2fm2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fm2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9ELS8_9HEPC Q9ELS8_9HEPC]
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===HCV NS3-4A protease domain complexed with a ketoamide inhibitor, SCH446211===
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==See Also==
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*[[Helicase 3D structures|Helicase 3D structures]]
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*[[Virus protease 3D structures|Virus protease 3D structures]]
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__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 16352601 is the PubMed ID number.
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[[Category: Hepacivirus C]]
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[[Category: Hepatitis C virus genotype 1a]]
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{{ABSTRACT_PUBMED_16352601}}
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[[Category: Large Structures]]
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[[Category: Bogen SL]]
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==About this Structure==
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[[Category: Bourne N]]
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2FM2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FM2 OCA].
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[[Category: Chase R]]
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[[Category: Chen T]]
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==Reference==
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[[Category: Lemon SM]]
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Mutations conferring resistance to SCH6, a novel hepatitis C virus NS3/4A protease inhibitor. Reduced RNA replication fitness and partial rescue by second-site mutations., Yi M, Tong X, Skelton A, Chase R, Chen T, Prongay A, Bogen SL, Saksena AK, Njoroge FG, Veselenak RL, Pyles RB, Bourne N, Malcolm BA, Lemon SM, J Biol Chem. 2006 Mar 24;281(12):8205-15. Epub 2005 Dec 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16352601 16352601]
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[[Category: Malcolm BA]]
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[[Category: Hepatitis c virus]]
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[[Category: Njoroge FG]]
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[[Category: Single protein]]
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[[Category: Prongay A]]
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[[Category: Bogen, S L.]]
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[[Category: Pyles RB]]
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[[Category: Bourne, N.]]
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[[Category: Saksena AK]]
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[[Category: Chase, R.]]
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[[Category: Skelton A]]
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[[Category: Chen, T.]]
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[[Category: Tong X]]
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[[Category: Lemon, S M.]]
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[[Category: Veselenak RL]]
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[[Category: Malcolm, B A.]]
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[[Category: Yi M]]
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[[Category: Njoroge, F G.]]
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[[Category: Prongay, A.]]
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[[Category: Pyles, R B.]]
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[[Category: Saksena, A K.]]
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[[Category: Skelton, A.]]
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[[Category: Tong, X.]]
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[[Category: Veselenak, R L.]]
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[[Category: Yi, M.]]
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[[Category: Hcv]]
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[[Category: Hepatitis c virus]]
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[[Category: Ketoamide inhibitor]]
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[[Category: Ns3/4a protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:19:45 2008''
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Current revision

HCV NS3-4A protease domain complexed with a ketoamide inhibitor, SCH446211

PDB ID 2fm2

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